本文選題：普羅布考　切入點(diǎn)：腦梗塞　出處：《中國(guó)現(xiàn)代醫(yī)學(xué)雜志》2017年06期 　論文類型：期刊論文

【摘要】：目的探討普羅布考治療對(duì)腦梗塞進(jìn)展期患者活化部分凝血活酶時(shí)間(APTT)、纖維蛋白原及血液流變學(xué)的影響,為普羅布考治療腦梗塞的臨床應(yīng)用提供依據(jù)。方法選取2014年1月-2015年1月該院神經(jīng)內(nèi)科收治的80例腦梗塞進(jìn)展期患者為研究對(duì)象,隨機(jī)分為研究組和對(duì)照組,每組40例,對(duì)照組采取常規(guī)藥物治療,研究組在對(duì)照組基礎(chǔ)上加用普羅布考,比較兩組患者治療前后的APTT、纖維蛋白原及血液流變學(xué)的變化。結(jié)果研究組的療效與對(duì)照組比較,差異統(tǒng)計(jì)學(xué)意義(P0.05)。研究組患者治療后APTT較治療前延長(zhǎng),且治療后30 d時(shí)間較治療后15 d延長(zhǎng)。研究組患者治療后APTT與對(duì)照組比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。研究組患者治療后纖維蛋白原水平較治療前降低,且治療后30 d水平低于治療后15 d;研究組患者治療后的纖維蛋白原水平與對(duì)照組比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。研究組患者治療后的血漿黏度、全血高切黏度及全血低切黏度較治療前均降低,且治療后30 d較治療后15 d降低;研究組患者治療后血漿黏度、全血高切黏度及全血低切黏度與對(duì)照組比較,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論普羅布考治療腦梗塞進(jìn)展期患者療效顯著,能夠延長(zhǎng)APTT,降低纖維蛋白原水平,降低血漿黏度、全血高切黏度及全血低切黏度,值得推廣應(yīng)用。
[Abstract]:Objective to investigate the effect of probucol treatment on cerebral infarction patients with advanced activated partial thromboplastin time (APTT), effects of fibrinogen and blood rheology, provide the basis for clinical application of probucol in treatment of cerebral infarction. Methods from January 2014 -2015 year in January the hospital neurology department treated 80 cases of cerebral infarction patients in advanced stage the object of study, were randomly divided into study group and control group, 40 cases in each group, the control group take routine treatment, the study group compared with the control group were treated with probucol, two groups were compared before and after treatment of APTT, the changes of fibrinogen and blood rheology. Results the study group compared with the control group, the difference was statistically significant (P0.05). To extend the study group after treatment in patients with APTT compared with those before treatment, and the treatment time is 30 d after 15 d after treatment. The study group prolonged after treatment in patients with APTT compared with the control group, the difference was statistically significant (P 0.05). Study on fibrinogen levels than patients in the treatment group after treatment decreased below 30 d and after treatment with 15 d after treatment; group of patients in the study group after treatment of fibrinogen level with the control, the difference was statistically significant (P0.05). The blood viscosity groups after treatment, whole blood high the viscosity and blood viscosity were decreased significantly compared with before treatment, after treatment and 30 d compared to 15 d after treatment decreased; study group patients after plasma viscosity, whole blood viscosity and group compared with the control of blood viscosity, the difference was statistically significant (P0.05). Conclusion probucol treatment in patients with advanced cerebral infarction curative effect obviously, can prolong APTT, reducing the level of fibrinogen, reduce plasma viscosity, whole blood viscosity and blood viscosity, it is worthy of popularization and application.

【作者單位】： 西南醫(yī)科大學(xué)附屬醫(yī)院藥劑科;
【分類號(hào)】：R743.33

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