本文選題：膠質(zhì)瘤　切入點(diǎn)：瘤周水腫　出處：《蘭州大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：從臨床表現(xiàn)、影像學(xué)、術(shù)中所見及病理學(xué)的角度研究影響膠質(zhì)瘤瘤周水腫(PTBE)的因素,探討膠質(zhì)瘤瘤周水腫的臨床意義。 方法：收集65例首發(fā)膠質(zhì)瘤患者的病歷資料,頭顱MRI、病理學(xué)資料,根據(jù)核磁共振資料計算獲得瘤周水腫指數(shù)(EI),術(shù)中記錄腫瘤質(zhì)地和血供。分別研究臨床表現(xiàn)、腫瘤部位、體積、術(shù)中情況及病理類型對PTBE發(fā)生率及EI的影響。 結(jié)果：1.膠質(zhì)瘤瘤周水腫EI與性別、年齡及患者癥狀持續(xù)時間無相關(guān)關(guān)系(P0.05)；EI與入院KPS評分呈負(fù)相關(guān)關(guān)系(相關(guān)系數(shù)為-0.440)。2.EI與腫瘤質(zhì)地?zé)o關(guān)(P0.05),與腫瘤血供相關(guān)(P0.05)。3.不同部位的膠質(zhì)瘤EI值有顯著差異性(P0.05)。4.EI與腫瘤大小呈負(fù)相關(guān)關(guān)系(相關(guān)系數(shù)為-0.514)。5.EI與腫瘤病理類型無關(guān)(P0.05),但與病理級別和Ki-67陽性細(xì)胞檢出率相關(guān)(P0.05)。 結(jié)論：膠質(zhì)瘤瘤周水腫程度與臨床癥狀輕重、腫瘤部位、大小、血供、病理級別及惡性程度有關(guān),與性別、年齡、癥狀持續(xù)時間、腫瘤質(zhì)地及病理類型無關(guān)。
[Abstract]:Objective: to study the factors affecting PTBEs in the clinical manifestations, imaging, intraoperative findings and pathology, and to explore the clinical significance of peritumoral edema of gliomas. Methods: the medical records, head MRI and pathological data of 65 patients with first-episode glioma were collected. According to the MRI data, the peri-tumor edema index (EI) was obtained, and the tumor texture and blood supply were recorded during the operation. The effect of volume, intraoperative condition and pathological type on the incidence and ei of PTBE. Results 1. Ei and sex of peritumoral edema in gliomas, There was no correlation between age and duration of symptoms. There was a negative correlation between P0.05E and admission KPS score (correlation coefficient was -0.440? 2.EI was not correlated with tumor texture (P 0.05), and there was significant difference between ei value of glioma and tumor blood supply (P0.05. 4. Ei) and tumor blood supply. There was a negative correlation between tumor size and tumor size (the correlation coefficient was -0.514). 5. Ei was not related to the pathological type of the tumor (P 0.05), but to the pathological grade and the detection rate of Ki-67 positive cells (P 0.05). Conclusion: the degree of peritumoral edema is related to clinical symptoms, tumor location, size, blood supply, pathological grade and malignancy, but not to sex, age, duration of symptoms, tumor texture and pathological type.
【學(xué)位授予單位】：蘭州大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R739.41

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本文編號：1567447