本文關(guān)鍵詞： 偏頭痛 COMT 基于體素的形態(tài)測(cè)量學(xué)方法 大腦結(jié)構(gòu)網(wǎng)絡(luò)　出處：《西安電子科技大學(xué)》2014年碩士論文　論文類型：學(xué)位論文

【摘要】：偏頭痛是一種很常見的復(fù)發(fā)性神經(jīng)疾病,發(fā)病時(shí)往往伴隨畏聲、畏光、惡心、嘔吐心率加快等癥狀。在亞洲人群中,偏頭痛的發(fā)病率高達(dá)8.4%~12.7%,且單次發(fā)作持續(xù)時(shí)間一般為4~72h,這給學(xué)習(xí)、工作和生活帶來(lái)了很大的困擾,嚴(yán)重影響著個(gè)人和家庭的幸福生活。所以,研究偏頭痛的發(fā)病機(jī)制具有重要的現(xiàn)實(shí)意義�，F(xiàn)有研究表明遺傳因素對(duì)偏頭痛患者的病理生理學(xué)機(jī)制有一定的影響。COMT基因作為影響疼痛的遺傳因素之一,已經(jīng)被提出可能與偏頭痛的發(fā)病率以及發(fā)病機(jī)理存在緊密的聯(lián)系。目前,人腦連接組結(jié)合基因分析的研究已經(jīng)發(fā)現(xiàn),不同基因型會(huì)導(dǎo)致大腦結(jié)構(gòu)和功能網(wǎng)絡(luò)的差異。因此,我們猜測(cè)不同COMT基因型偏頭痛患者的生理學(xué)機(jī)制可能與大腦的網(wǎng)絡(luò)模式有關(guān)。為了驗(yàn)證上述猜測(cè),本研究根據(jù)COMT Val158Met基因型,分別將111名健康被試和136名偏頭痛患者分為Val/Val和攜帶Met兩個(gè)子組,基于T1結(jié)構(gòu)像和功能磁共振圖像,采用基于體素的形態(tài)測(cè)量學(xué)方法和功能連接分析方法,評(píng)估COMT基因變異對(duì)于偏頭痛患者大腦結(jié)構(gòu)和功能網(wǎng)絡(luò)的影響,從而研究無(wú)先兆偏頭痛患者和健康被試中COMT基因型和疾病間在大腦網(wǎng)絡(luò)中可能的交互作用,并進(jìn)一步針對(duì)攜帶Met的偏頭痛患者,利用纖維束追蹤技術(shù)和多模態(tài)融合分析方法,結(jié)合復(fù)雜網(wǎng)絡(luò)理論,探索偏頭痛患者大腦結(jié)構(gòu)網(wǎng)絡(luò)內(nèi)潛在的異常連接并考察結(jié)構(gòu)連接-功能連接的耦合情況。本文的主要結(jié)果如下:1.偏頭痛疾病和基因之間的交互作用主要呈現(xiàn)在海馬區(qū)域,并且與Val/Val型健康被試相比,Val/Val型偏頭痛患者在海馬區(qū)的灰質(zhì)密度值也顯著性降低;2.以海馬為感興趣腦區(qū),進(jìn)行種子點(diǎn)功能連接分析。結(jié)果發(fā)現(xiàn),與攜帶Met型患者相比,Val/Val型患者在海馬到內(nèi)側(cè)前額葉的功能連接值顯著性減小;3.針對(duì)攜帶Met基因型偏頭痛患者,進(jìn)行結(jié)構(gòu)網(wǎng)絡(luò)屬性分析。結(jié)果表明,與健康被試相比,患者的大腦網(wǎng)絡(luò)拓?fù)鋵傩燥@著性改變,并且結(jié)構(gòu)連接和功能連接的耦合情況發(fā)生明顯改變。綜上所述,不同基因型偏頭痛患者的大腦網(wǎng)絡(luò)存在著形態(tài)學(xué)上的差異,這在一定程度上為理解有家族遺傳史偏頭痛的病理機(jī)制提供了影像學(xué)證據(jù)。
[Abstract]:Migraine is a very common recurrent neurological disease, often accompanied by fear of sound, photophobia, nausea, vomiting? Symptoms such as accelerated heart rate. In Asian people, the incidence of migraine is as high as 8.4% 12.7and the duration of a single attack is usually 40.72 h, which is for study. Work and life bring a lot of trouble, seriously affect the well-being of individuals and families. So. It is of great practical significance to study the pathogenesis of migraine. Existing studies have shown that genetic factors have certain influence on pathophysiological mechanism of migraine patients. COMT gene is one of the genetic factors affecting pain. . It has been suggested that there may be a close association with the incidence and pathogenesis of migraine. Different genotypes lead to differences in brain structure and functional networks. Therefore, we speculate that the physiological mechanism of migraine patients with different COMT genotypes may be related to brain network patterns. According to the genotype of COMT Val158Met, 111 healthy subjects and 136 migraine patients were divided into two subgroups: Val/Val and carrying Met. Based on T1 structure image and functional magnetic resonance imaging, the effects of COMT gene mutation on brain structure and functional network of migraine patients were evaluated by morphometry and functional connection analysis based on voxel. In order to study the possible interaction between COMT genotypes and diseases in the brain network in patients without aura migraine and healthy subjects, and further targeted at migraine patients with Met. The fiber bundle tracing technique and multi-modal fusion analysis method are used to combine the complex network theory. To explore the potential abnormal connections in the brain structure network of migraine patients and to investigate the coupling of structural connection-functional connections. The main results of this paper are as follows:. 1. The interaction between migraine disease and genes is mainly present in the hippocampus. The gray matter density in hippocampus of patients with Val migraine was significantly lower than that of healthy subjects with Val/Val. 2. Using the hippocampus as the brain area of interest, the functional connections of seed points were analyzed. The results showed that compared with the patients with Met type. The functional connections between the hippocampus and the medial prefrontal lobe were significantly decreased in patients with Val/Val type. 3. The structural network properties of patients with Met genotype migraine were analyzed. The results showed that the topological properties of brain network in patients with Met genotype were significantly changed compared with healthy subjects. And the coupling between structural and functional connections has changed significantly. In conclusion, there are morphological differences in brain network among different genotypic migraine patients. To some extent, this provides imaging evidence for understanding the pathological mechanism of migraine with family genetic history.
【學(xué)位授予單位】：西安電子科技大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R747.2

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1 尹青;不同COMT基因型的偏頭痛患者大腦白質(zhì)網(wǎng)絡(luò)研究[D];西安電子科技大學(xué);2014年

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本文編號(hào)：1471024