【摘要】：目的：應(yīng)用血氧水平依賴功能磁共振成像（BOLD-fMRI）定量分析健康自愿者和急性腦梗死偏癱患者握拳運動后初級運動區(qū)（M1）的激活體積與激活強度，，探討B(tài)OLD-fMRI正常人及急性腦梗死偏癱患者中的應(yīng)用價值。 方法：對20名健康志愿者（正常組）及16名急性腦梗死偏癱患者（偏癱組）雙手分別行握拳運動BOLD-fMRI檢查，應(yīng)用統(tǒng)計參數(shù)圖（SPM5）對功能圖像進行處理分析，觀察受試者全腦激活情況，并用xjView8軟件得到全腦最大信號強度的MNI坐標(biāo)及解剖位置分布。同時選取M1區(qū)為感興趣區(qū)（ROI），使用SPSS19.0對M1區(qū)激活體積、激活強度進行定量分析。 結(jié)果：2名正常組及3名偏癱組受試者因頭動校正結(jié)果提示頭動幅度控制不理想，受試者數(shù)據(jù)排除。除2例偏癱組受試者患手握拳全腦未見激活外，正常組及偏癱組受試者單手握拳運動全腦均可見散在激活，且均以對側(cè)M1區(qū)激活明顯。正常組雙手握拳運動對側(cè)M1區(qū)激活體積及激活強度差異均無統(tǒng)計學(xué)意義（P0.05）；偏癱組健手握拳與患手握拳對側(cè)M1區(qū)激活體積及激活強度差異均有統(tǒng)計學(xué)意義（P0.05）；偏癱組健側(cè)手握拳與正常組同側(cè)手握拳運動所致對側(cè)M1區(qū)激活體積及激活強度均無顯著統(tǒng)計學(xué)差異（P0.05），偏癱組患側(cè)手握拳與正常組同側(cè)手握拳所致對側(cè)M1區(qū)激活體積差異有統(tǒng)計學(xué)意義（P0.05），而激活強度差異無統(tǒng)計學(xué)意義（P0.05）。 結(jié)論：BOLD-fMRI能準(zhǔn)確定位及定量分析感興趣腦功能區(qū)的激活體積及強度，為判斷急性腦梗死后運動功能的改變提供了一種簡單有效的方法。
[Abstract]:Objective: to quantitatively analyze the activation volume and intensity of primary motor area (M1) in healthy volunteers and patients with acute cerebral infarction hemiplegia by using blood oxygen level dependent functional magnetic resonance imaging (BOLD-fMRI). To investigate the value of BOLD-fMRI in patients with acute cerebral infarction and hemiplegia. Methods: 20 healthy volunteers (normal group) and 16 hemiplegic patients with acute cerebral infarction (hemiplegia group) were examined with BOLD-fMRI. The functional images were processed by statistical parameter map (SPM5). The activation of the whole brain was observed and the MNI coordinates and anatomic distribution of the maximum signal intensity of the whole brain were obtained by xjView8 software. At the same time, M1 region was selected as the region of interest (ROI),). SPSS19.0 was used to quantitatively analyze the activation volume and intensity of M1 region. Results: two normal subjects and three hemiplegic subjects were excluded because the head-motion correction results suggested that the head-motion amplitude control was not satisfactory. With the exception of 2 hemiplegic subjects who had no activation in the whole brain of the affected hand grip, the whole brain of the normal and hemiplegic subjects with one hand clenched fist was scattered in the whole brain, and all of them were activated obviously in the contralateral M1 area. There was no significant difference in activation volume and activation intensity between normal group and hemiplegic group in contralateral M1 area (P0.05), while there were significant differences in activation volume and activation intensity between healthy hand grip and affected hand grip in hemiplegia group (P0.05). There was no significant difference in the activation volume and intensity of the contralateral M1 area between the hemiplegic group and the normal group (P0.05). There was significant difference in activation volume of contralateral M1 area between hemiplegic group and normal group (P0.05), but there was no significant difference in activation intensity between hemiplegic group and normal group (P0.05). Conclusion: BOLD-fMRI can accurately locate and quantitatively analyze the activation volume and intensity of the cerebral functional area of interest, which provides a simple and effective method for judging the changes of motor function after acute cerebral infarction.
【學(xué)位授予單位】：重慶醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2013
【分類號】：R445.2;R743.3

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