對比劑相關(guān)急性腎損傷對缺血性腦卒中患者近期預(yù)后的影響
發(fā)布時間：2018-11-28 12:44
【摘要】：目的:觀察缺血性卒中患者腦血管造影后對比劑相關(guān)急性腎損傷(CI-AKI)對住院死亡率及1年死亡率的影響。方法:回顧性納入2009-01-01~2013-12-31在廣東省人民醫(yī)院接受腦血管造影介入術(shù)的缺血性腦卒中患者,收集患者造影前、造影過程中及造影后相關(guān)臨床資料,通過多因素回歸模型分析CI-AKI對住院死亡率及1年死亡率的影響。結(jié)果:共有1 820例接受腦血管造影的缺血性腦卒中患者納入本研究,其中81例(4.5%)患者發(fā)生了CI-AKI。多因素Logistic回歸模型顯示腦血管造影后CI-AKI增加患者住院死亡風(fēng)險(優(yōu)勢比OR=3.99;95%CI 1.43~11.14;P=0.008),同時多因素COX回歸模型顯示CI-AKI也是1年死亡的獨立危險因素(風(fēng)險比HR=1.96;95%CI 1.18~3.26;P=0.009)。結(jié)論:腦血管造影后CI-AKI是缺血性卒中患者住院死亡及1年死亡的獨立危險因素,對接受腦血管造影患者采取有效措施預(yù)防CI-AKI十分必要。
[Abstract]:Objective: to observe the effect of contrast agent-associated acute renal injury (CI-AKI) on hospital mortality and 1-year mortality in patients with ischemic stroke. Methods: the clinical data of patients with ischemic stroke undergoing interventional cerebrovascular angiography in Guangdong Provincial people's Hospital were retrospectively collected before, during and after angiography. The effects of CI-AKI on hospital mortality and 1 year mortality were analyzed by multivariate regression model. Results: a total of 1 820 ischemic stroke patients underwent cerebrovascular angiography were included in this study, of which 81 (4.5%) had CI-AKI.. Multivariate Logistic regression model showed that CI-AKI increased the risk of death in hospital after cerebrovascular angiography (OR=3.99;95%CI 1.43 / 11.14). At the same time, the multivariate COX regression model showed that CI-AKI was also an independent risk factor for one year's death (the risk ratio was 1.183.26p 0.009). Conclusion: CI-AKI after cerebral angiography is an independent risk factor of death in hospital and one year in patients with ischemic stroke. It is necessary to take effective measures to prevent CI-AKI in patients undergoing cerebrovascular angiography.
【作者單位】： 廣東省人民醫(yī)院腎內(nèi)科廣東省醫(yī)學(xué)科學(xué)院;
【基金】：國家臨床重點�？平ㄔO(shè)項目 國家自然科學(xué)基金面上項目(81170683)
【分類號】：R743.3
本文編號：2362855
[Abstract]:Objective: to observe the effect of contrast agent-associated acute renal injury (CI-AKI) on hospital mortality and 1-year mortality in patients with ischemic stroke. Methods: the clinical data of patients with ischemic stroke undergoing interventional cerebrovascular angiography in Guangdong Provincial people's Hospital were retrospectively collected before, during and after angiography. The effects of CI-AKI on hospital mortality and 1 year mortality were analyzed by multivariate regression model. Results: a total of 1 820 ischemic stroke patients underwent cerebrovascular angiography were included in this study, of which 81 (4.5%) had CI-AKI.. Multivariate Logistic regression model showed that CI-AKI increased the risk of death in hospital after cerebrovascular angiography (OR=3.99;95%CI 1.43 / 11.14). At the same time, the multivariate COX regression model showed that CI-AKI was also an independent risk factor for one year's death (the risk ratio was 1.183.26p 0.009). Conclusion: CI-AKI after cerebral angiography is an independent risk factor of death in hospital and one year in patients with ischemic stroke. It is necessary to take effective measures to prevent CI-AKI in patients undergoing cerebrovascular angiography.
【作者單位】： 廣東省人民醫(yī)院腎內(nèi)科廣東省醫(yī)學(xué)科學(xué)院;
【基金】：國家臨床重點�？平ㄔO(shè)項目 國家自然科學(xué)基金面上項目(81170683)
【分類號】：R743.3
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