早期他汀治療對(duì)急性腦梗死靜脈溶栓患者血漿基質(zhì)金屬蛋白酶-9水平及短期預(yù)后的影響
[Abstract]:Objective to investigate the effect of early statin therapy on plasma matrix metalloproteinase-9 (MMPs) (MMP)-9 levels and short-term prognosis in patients with acute cerebral infarction after intravenous thrombolytic therapy. Methods 193 patients with acute cerebral infarction were divided into early statin group (72 cases) and post thrombolytic statin group (121 cases). The plasma MMP-9 levels before and after thrombolysis were measured by ELISA method at 24 h and 72 h before and 6 h after thrombolysis. The prognosis of the patients was evaluated by mRS score on the 7th and 90th day, and the incidence of symptomatic intracranial hemorrhage was compared between the two groups. Results there was no significant difference in sex, age, thrombolytic time window, blood pressure, past history, laboratory examination, NIHSS score, TOAST classification and OCSP stroke type between the treatment group and the early treatment group (P0.05). There was no significant difference in plasma MMP-9 levels between the two groups before thrombolysis (P0.05). Compared with the post-thrombolytic statin treatment group, the MMP-9 levels in the early statin treatment group were significantly lower than those in the early statin group at 12 h after thrombolysis at 24 h and 72 h after thrombolytic therapy. There was no significant difference in the incidence of symptomatic intracranial hemorrhage after thrombolytic therapy and neurological deficit score in early statins group (P0.05). The rate of good prognosis in the early statin group was significantly higher than that in the post-thrombolytic statin group (P0.05). Conclusion early statin therapy can inhibit the level of MMP-9 in patients with acute cerebral infarction without increasing the risk of symptomatic intracranial hemorrhage after thrombolytic therapy and can improve the short-term prognosis of acute cerebral infarction.
【作者單位】： 南京醫(yī)科大學(xué)附屬南京醫(yī)院(南京市第一醫(yī)院)神經(jīng)內(nèi)科;
【分類(lèi)號(hào)】：R743.3
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