本文關(guān)鍵詞：簡化版肝性腦病心理測試評分量表對輕微型肝性腦病的診斷價(jià)值，由筆耕文化傳播整理發(fā)布。

簡化版肝性腦病心理測試評分量表對輕微型肝性腦病的診斷價(jià)值

Diagnostic value of a simplified psychometric hepatic encephalopathy scale for minimal hepatic encephalopathy

[1] [2] [3] [4] [5]

Chen Lei, Zhao Jiangming, Wu Yuanbo, Li Wenting, Wu A imei. （Department of Neurology, Affiliated Provincial Hospital of Anhui Medical University, Hefei 230001, China）

[1]安徽醫(yī)科大學(xué)附屬省立醫(yī)院神經(jīng)內(nèi)科,合肥230001; [2]安徽醫(yī)科大學(xué)附屬省立醫(yī)院感染科,合肥230001; [3]安徽醫(yī)科大學(xué)附屬合肥市第二人民醫(yī)院神經(jīng)內(nèi)科,合肥230011

文章摘要：目的 探討簡化版肝性腦病心理測試評分（SPHES）量表對輕微型肝性腦�。∕HE）的診斷及顯性肝性腦�。∣HE）的預(yù)測價(jià)值. 方法 選擇安徽醫(yī)科大學(xué)附屬省立醫(yī)院感染科自2012年10月至2013年6月收治的均無OHE的乙肝肝硬化患者70例作為試驗(yàn)組,以同期健康體檢中心志愿者72例作為健康對照組,分別完成肝性腦病心理測試評分（PHES）量表.以健康對照組建立PHES系統(tǒng)5個(gè)測試項(xiàng)目的預(yù)期正常參考值公式,應(yīng)用Logistic回歸分析逐步縮減PHES的子量表個(gè)數(shù)得到SPHES量表.對試驗(yàn)組患者完成SPHES量表并隨訪1年,篩查MHE的患病率和OHE的發(fā)生. 結(jié)果 PHES量表易受年齡和教育年限的影響.應(yīng)用PHES和SPHES量表篩查試驗(yàn)組患者M(jìn)HE的患病率,分別為31/70、29/70,比較差異無統(tǒng)計(jì)學(xué)意義（P＞0.05）;21例肝硬化患者進(jìn)展為OHE,PHES量表、SPHES量表診斷為MHE的患者OHE發(fā)生率比較差異無統(tǒng)計(jì)學(xué)意義（P＞0.05）.結(jié)論 SPHES量表在診斷MHE和預(yù)測OHE的發(fā)生方面與PHES量表具有同等價(jià)值,且更簡便,適于臨床篩查.

Abstr：Objective The psychometric hepatic encephalopathy scale （PHES）,including five psychometric tests,is a standard for the diagnosis of minimal hepatic encephalopathy （MHE） and enjoys predictive value of overt hepatic encephalopathy （OHE）.We investigate whether a simplified PHES is as useful as the whole PHES.Methods Seventy consecutive hepatitis B cirrhotic patients without OHE,admitted to our hospital from October 2012 to June 2013,and other 72 healthy volunteers were chosen in our study.PHES was performed in both groups.Expected normal reference value formula were established based on the 5 psychometric tests in healthy controls,and backward logistic regression was performed by eliminating stepwise variables of PHES to get a simplified PHES （SPHES）.Then,SPHES was performed on the 70 patients and followed up for a year to detect the prevalence rate of MHE and OHE.Results PHES was easily influenced by age and educational level.In patients with liver cirrhosis,44.29% patients （31/70） had MHE based on PHES and 41.43% （9/70） had MHE based on SPHES,without significant differences （P〉0.05）.According to the follow-up study,21 patients developed OHE; the number of developing OHE showed no significant difference between MHE patients dignosed by PHES and SPHES （P〉0.05）.Conclusion SPHES is as good as PHES in diagnosing MHE and predicting the occurrence of OHE,which consumes less time and is more suitable for clinical screening.

文章關(guān)鍵詞：

Keyword：:Simplified psychometric hepatic encephalopathy scale Liver cirrhosis Minimal hepatic encephalopathy Overt hepatic encephalopathy

課題項(xiàng)目：安徽省自然科學(xué)青年基金（11040606Q09）;安徽醫(yī)科大學(xué)附屬省立醫(yī)院三新項(xiàng)目

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  本文關(guān)鍵詞：簡化版肝性腦病心理測試評分量表對輕微型肝性腦病的診斷價(jià)值，由筆耕文化傳播整理發(fā)布。