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顱腦損傷中醫(yī)證候的聚類分析研究

發(fā)布時間:2018-07-12 08:28

  本文選題:顱腦損傷 + 聚類分析; 參考:《廣西醫(yī)科大學(xué)》2013年碩士論文


【摘要】:目的:采用聚類分析方法(Cluster analysis),對顱腦損傷中醫(yī)證候特征及分布規(guī)律進行探討,為建立和完善顱腦損傷的中醫(yī)規(guī)范化辨證治療體系提供科學(xué)依據(jù)。 方法:根據(jù)病例納入標(biāo)準(zhǔn)及排除標(biāo)準(zhǔn)收集2012年5月至2013年3月廣西醫(yī)科大學(xué)第一附屬醫(yī)院中醫(yī)科、神經(jīng)外科病房和瑞康醫(yī)院神經(jīng)外科病房的顱腦損傷患者190例,記錄所有患者的性別、年齡、病程、頭顱CT/MRI診斷、損傷原因、合并癥/并發(fā)癥、主要臨床表現(xiàn)、舌脈象等信息,運用SPSS17.0統(tǒng)計軟件,建立所有患者的個人信息條目數(shù)據(jù)庫,對證候條目采用分層聚類分析。根據(jù)聚類結(jié)果,由專家對聚類分析的初始模型討論后,最終確定證型名稱及證候特征。 結(jié)果:190例顱腦損傷患者中醫(yī)證候信息橫斷面調(diào)查顯示:面色晦暗或黧黑、皮膚青紫瘀腫、口唇紫暗或暗紅、皮膚粗糙、咳痰或喉中痰鳴、大便干、淡舌、細脈等8個癥狀,在重型顱腦損傷與非重型顱腦損傷兩組病例中,出現(xiàn)頻率均≥30%。聚類分析結(jié)果顯示:重型顱腦損傷13例急性期患者為痰瘀閉竅證,39例恢復(fù)期患者中,痰熱蒙竅證20例(51.3%)、痰蒙清竅兼氣血兩虛證19例(48.7%);非重型顱腦損傷70例急性期患者中,瘀熱內(nèi)擾證32例(45.7%)、血瘀兼氣陰兩傷證38例(54.3%),68例恢復(fù)期患者中,痰濕阻竅兼氣虛證26例(38.2%)、瘀血阻絡(luò)證21例(30.9%)、氣血虧虛證21例(30.9%)。 結(jié)論:基于聚類分析研究,重型顱腦損傷急性期分為痰瘀閉竅證,恢復(fù)期分為痰熱蒙竅證、痰蒙清竅兼氣血兩虛證;非重型顱腦損傷急性期分為瘀熱內(nèi)擾證、血瘀兼氣陰兩傷證;恢復(fù)期分為痰濕阻竅兼氣虛證、瘀血阻絡(luò)證及氣血虧虛證。
[Abstract]:Objective: to explore the characteristics and distribution of TCM syndromes of craniocerebral injury by cluster analysis), so as to provide scientific basis for establishing and perfecting the system of TCM syndrome differentiation and treatment of craniocerebral injury. Methods: from May 2012 to March 2013, 190 patients with craniocerebral injury in Department of traditional Chinese Medicine, Department of Neurosurgery and Neurosurgical ward of Ruikang Hospital were collected according to the criteria of case inclusion and exclusion. The data of sex, age, course of disease, head CT / MRI diagnosis, injury cause, complication / complication, main clinical manifestation, tongue pulse were recorded. SPSS 17.0 statistical software was used to establish the database of personal information entries of all patients. Stratified cluster analysis was used to analyze the syndromes. According to the results of clustering, the initial model of cluster analysis was discussed by experts, and the name of syndromes and the characteristics of syndromes were finally determined. Results the cross-sectional investigation of TCM syndromes in 190 patients with craniocerebral injury showed that the symptoms were as follows: dark complexion or blackish brown skin, dark or dark red lip, rough skin, expectoration or phlegm in larynx, dry stool, light tongue, thin veins, etc. The frequency of severe craniocerebral injury and non-severe craniocerebral injury was 鈮,

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