發(fā)布時(shí)間：2018-06-28 13:06

  本文選題：創(chuàng)傷膿毒癥高遷移率族蛋白B + 白介素-��； 參考：《中華腫瘤防治雜志》2016年S2期

【摘要】：目的動(dòng)態(tài)監(jiān)測(cè)創(chuàng)傷膿毒癥及非膿毒癥血漿中HMGB-1、IL-13、IL-17的量,初步探究創(chuàng)傷膿毒癥發(fā)生發(fā)展中部分細(xì)胞因子的作用,為臨床治療提供依據(jù)。方法將江蘇大學(xué)附屬武進(jìn)醫(yī)院2013-10-2015-10收治的28例患者及體檢中心健康人群為研究對(duì)象。分為創(chuàng)傷膿毒癥組、創(chuàng)傷非膿毒癥組。其中創(chuàng)傷膿毒癥組14例、創(chuàng)傷非膿毒癥組14例及正常對(duì)照組20例。用酶聯(lián)免疫分析法測(cè)其血漿中HMGB-1、IL-13、IL-17的量。結(jié)果:HMGB-1、IL-13、IL-17的含量與對(duì)照組比較,在創(chuàng)傷膿毒癥組及創(chuàng)傷非膿毒癥組均明顯升高(P0.05);在創(chuàng)傷膿毒癥組,與創(chuàng)傷非膿毒癥組比較HMGB-1和IL-1的含量明顯升高(P0.05),而IL-17含量并沒(méi)有顯著提高,且各組組內(nèi)各時(shí)間點(diǎn)件沒(méi)有顯著差異。結(jié)論HMGB-1、IL-17,IL-13含量在創(chuàng)傷膿毒癥的病情演變中都起著重要的作用。及時(shí)監(jiān)測(cè)HMGB-1、IL-13的變化,可更敏感地判斷創(chuàng)傷膿毒癥的發(fā)生,評(píng)估其嚴(yán)重程度,為臨床治療提供依據(jù)。
[Abstract]:Objective to investigate the role of some cytokines in the pathogenesis and development of traumatic sepsis by dynamically monitoring the level of IL-13 IL-17 in plasma of traumatic sepsis and non-sepsis, and to provide evidence for clinical treatment. Methods 28 patients admitted to Wujin Hospital of Jiangsu University in 2013-10-2015-10 and healthy people in physical examination Center were studied. The patients were divided into trauma sepsis group and trauma non sepsis group. There were 14 cases of traumatic sepsis group, 14 cases of traumatic non-sepsis group and 20 cases of normal control group. The level of HMGB-1 IL-13 IL-17 in plasma was measured by enzyme-linked immunosorbent assay (Elisa). Results compared with the control group, the content of IL-17 in the 1: HMGB-1 group was significantly higher than that in the control group (P0.05), and in the traumatic sepsis group, the levels of HMGB-1 and IL-1 were significantly higher than those in the traumatic non-septic group (P0.05), but the level of IL-17 was not significantly increased. And there was no significant difference in each time point in each group. Conclusion the level of IL-17 IL-13 plays an important role in the development of traumatic sepsis. Monitoring the changes of HMGB-1 IL-13 in time can more sensitively judge the occurrence of traumatic sepsis, evaluate its severity, and provide evidence for clinical treatment.
【作者單位】： 常州市武進(jìn)人民醫(yī)院急診科;
【基金】：江蘇大學(xué)臨床醫(yī)學(xué)科技發(fā)展基金(JLY201200-40) 常州市社會(huì)發(fā)展科技計(jì)劃(CS20102002)
【分類號(hào)】：R459.7

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