本文選題：右美托咪定 + 胸部損傷��； 參考：《基因組學(xué)與應(yīng)用生物學(xué)》2017年03期

【摘要】：為探討右美托咪定后處理對胸部撞擊失血性休克和復(fù)蘇致急性肺損傷的影響。本研究選取45只SPF級雄性健康大鼠依據(jù)隨機數(shù)字表法將其分為3組,生理鹽水組、THSR組(胸部撞擊-失血性休克/復(fù)蘇組)和治療組(右美托咪定后處理組),THSR組和治療組制備胸部撞擊-失血性休克/復(fù)蘇致急性肺損傷模型,治療組模型建立后靜脈注射右美托咪定10μg/kg。模型制備6 h后采血,并處死大鼠。比較3組大鼠血氣分析指標(PaO_2,PaCO_2和氧合指數(shù)(OI))、肺組織病理形態(tài)、炎癥因子水平(血漿IL-6和IL-1β水平,肺泡灌洗液(BALF)中蛋白濃度和白細胞數(shù)目)以及肺組織中TLR4和p-p38MAPK表達水平。與生理鹽水組比較,THSR組和治療組的PaO_2升高(p0.05),OI降低(p0.05),THSR組PaCO_2升高(p0.05),THSR組和治療組的PaO_2、PaCO_2和OI差異具有統(tǒng)計學(xué)意義(p0.05);THSR組療組大鼠肺組織病理學(xué)損傷評分、血漿炎癥因子(BLAF蛋白,白細胞計數(shù),IL-6和IL-1β)水平最高,治療組次之,生理鹽水組最低(p0.05);THSR組和治療組大鼠肺組織中TLR4和p-p38MAPK表達較生理鹽水組上調(diào)(p0.05),治療組大鼠肺組織中TLR4和p-p38MAPK表達水平較THSR組顯著下調(diào)(p0.05)。右美托咪定后處理可明顯減輕胸部撞擊-失血性休克和復(fù)蘇致急性肺損傷,其起效機制可能與抑制TLR4/p-p38MAPK信號通路激活,降低機體炎性反應(yīng)有關(guān)。
[Abstract]:To investigate the effects of dexmetidine posttreatment on chest impact hemorrhagic shock and acute lung injury induced by resuscitation. In this study, 45 SPF male healthy rats were randomly divided into three groups. THSR group (chest impact-hemorrhagic shock / resuscitation group) and treatment group (dexmetomidine post-treatment group) were used to prepare acute lung injury models induced by chest impact-hemorrhagic shock / resuscitation. In the treatment group, 10 渭 g / kg dexmetomidine was injected intravenously after the establishment of the model. The blood was collected 6 hours after the model was made and the rats were killed. The blood gas analysis indexes of three groups were compared: PaO2 / Paco _ 2, oxygenation index (Oi), lung histopathology, inflammatory factor level (plasma IL-6 and IL-1 尾, protein concentration and white blood cell count in alveolar lavage fluid (BALFF), and expression of TLR4 and p-p38 MAPK in lung tissue. Compared with the normal saline group, the increase of Pao _ 2 in THSR group and the treatment group decreased the Paco _ 2 elevation of Paco _ 2 in THSR group, and the difference of PaO2Paco _ 2 and OI in THSR group and treatment group. There were significant differences between the two groups in lung histopathological injury score, plasma inflammatory factor BLAF protein and Pao _ 2 Paco _ 2 and OI in THSR group. The expression of TLR4 and p-p38 MAPK in lung tissue of rats in saline group and treatment group was higher than that in saline group, and the expression of TLR4 and p-p38 MAPK in lung tissue of treatment group was lower than that of THSR group. The expression of TLR4 and p-p38 MAPK in lung tissue of treatment group was significantly lower than that of THSR group. The posttreatment of dexmetidine could significantly reduce the acute lung injury induced by chest impact-hemorrhagic shock and resuscitation. The mechanism may be related to the inhibition of activation of TLR4 / p-p38 MAPK signaling pathway and the reduction of inflammatory response.
【作者單位】： 三峽大學(xué)仁和醫(yī)院重癥監(jiān)護室;
【分類號】：R459.7

【相似文獻】

相關(guān)期刊論文 前10條

1 宿英英,毛微,王海燕,王琳,車林海;老年急性重癥卒中并發(fā)急性肺損傷的危險因素分析[J];中國危重病急救醫(yī)學(xué);2000年12期

2 曹瓊;13例輸血相關(guān)急性肺損傷病例回顧[J];國外醫(yī)學(xué).輸血及血液學(xué)分冊;2000年04期

3 唐新明;譚成孝;徐燕;;輸血相關(guān)性急性肺損傷的診治一例報告[J];遵義醫(yī)學(xué)院學(xué)報;2007年01期

4 龔明;;輸血相關(guān)性急性肺損傷的臨床特征[J];內(nèi)科;2007年04期

5 劉文海;;輸血相關(guān)性急性肺損傷1例[J];鄖陽醫(yī)學(xué)院學(xué)報;2007年04期

6 王小紅;;6例溺水致急性肺損傷及急性呼吸窘迫綜合征的護理體會[J];中國鄉(xiāng)村醫(yī)藥;2008年06期

7 鄭立;;輸血相關(guān)性急性肺損傷1例[J];中國輸血雜志;2009年11期

8 劉俐偉;;輸血相關(guān)急性肺損傷6例誤診分析[J];臨床肺科雜志;2010年12期

9 張愛紅;趙鳳綿;王毅;梁瑩;張建平;孟趁喬;;采供血機構(gòu)預(yù)防輸血相關(guān)急性肺損傷的策略[J];中國輸血雜志;2010年09期

10 劉松凱;;輸血相關(guān)性急性肺損傷略述[J];中國中醫(yī)藥現(xiàn)代遠程教育;2011年12期

相關(guān)會議論文 前7條

1 黃秋霞;;法樂氏四聯(lián)癥根治術(shù)后急性肺損傷的護理[A];外科重癥監(jiān)護�？浦R培訓(xùn)暨學(xué)術(shù)交流會論文集[C];2008年

2 張茂;;急性肺損傷——超聲能幫助我們什么?[A];《中華急診醫(yī)學(xué)雜志》第八屆組稿會暨急診醫(yī)學(xué)首屆青年論壇論文匯編[C];2009年

3 張世訓(xùn);呂紅娟;;輸血相關(guān)急性肺損傷[A];中國輸血協(xié)會第四屆輸血大會論文集[C];2006年

4 袁琴芳;曹玲芳;陳芳燕;;嚴重?zé)齻蟛l(fā)急性肺損傷的護理對策[A];中華醫(yī)學(xué)會燒傷外科學(xué)分會2009年學(xué)術(shù)年會論文匯編[C];2009年

5 張穎;張煒;張雪;;冠脈介入治療術(shù)后嚴重血小板減少癥合并急性肺損傷患者的護理一例[A];中國心臟大會（CHC）2011暨北京國際心血管病論壇論文集[C];2011年

6 陳光建;邱海波;陸曉e，

本文編號：2030926