本文關(guān)鍵詞：CRRT在膿毒血癥急性腎損傷患者救治中的臨床研究，，由筆耕文化傳播整理發(fā)布。

CRRT在膿毒血癥急性腎損傷患者救治中的臨床研究

Clinical Study of CRRT in the Treatment of Patients with Sepsis Acute Kidney Injury

[1] [2] [3]

HU Jian, SHANG Wei-ming, WANG Feng （Critical Care Medicine Department, the First Hospital of Danjiangkou City,Danjiangkou 442700 China）

[1]丹江口市第一醫(yī)院急診科,湖北丹江口442700; [2]丹江口市第一醫(yī)院重癥醫(yī)學(xué)科,湖北丹江口442700

文章摘要：目的集中探討采用針對膿毒血癥急性腎損傷（AKI）患者采用連續(xù)性腎臟代替治療（continunous renal replacement therapy,CRRT）進(jìn)行救治過程中的臨床研究。方法選取膿毒血癥急性腎損傷患者200例,隨機(jī)分為采用CRRT治療的觀察組和采用常規(guī)藥物治療的對照組,對采用不同方法進(jìn)行治療的兩組患者救治過程中的臨床指標(biāo)變化進(jìn)行對比分析。結(jié)果在為期30天的臨床療效的比較中,觀察組較對照組在生存率和死亡率的比較中,均具有明顯生存優(yōu)勢,差異較大,具有統(tǒng)計學(xué)意義（P〈0.05）。對照組在AKI分期的比較中,針對NⅠ、NⅡ,存活患者較死亡患者差異不大,不具有統(tǒng)計學(xué)意義（P〉0.05）;在NⅢ的比較中,存活患者明顯低于死亡患者,具有明顯的統(tǒng)計學(xué)意義（P〈0.01）;而觀察組患者在AKI分期的比較中,在N1和NⅢ的比較中,存活患者較死亡患者差異較大,具有明顯的統(tǒng)計學(xué)意義（P〈0.01）;在合并癥的發(fā)病率中的比較中,兩組患者中存活患者的發(fā)病率明顯低于死亡患者,差異較大,具有明顯的統(tǒng)計學(xué)意義（P〈0.01）;觀察組患者中,存活患者較死亡患者在慢性阻塞性肺炎治療的時間間隔的比較中差異不大,不具有統(tǒng)計學(xué)意義（P〉0.05）;但是存活患者在從入ICU到入行CRRT的時間間隔明顯短于死亡患者,差異較大,具有明顯的統(tǒng)計學(xué)意義（P〈0.01）。結(jié)論CRRT在對于膿毒血癥急性腎損傷患者治療的過程中可有效的清除炎癥因子,從發(fā)病機(jī)制上降低疾病的死亡率,維持內(nèi)環(huán)境的相對穩(wěn)定性,盡早使用CRRT治療可有效地提高患者的30天存活率。

Abstr：Objective To investigate the clinical application value of continuous renal replacement therapy（ CRRT） in the treatment of patients with sepsis acute kidney injury（ AKI）. Methods 200 patients with septic acute kidney injury were randomly divided into observation group（ 100 patients treated with CRRT） and control group（ 100 patients treated with conventional drugs）. The changes of clinical indexes in both groups were analyzed. Results The survival and mortality rate in observation group during 30 days treatment had obvious advantage compared with control group（P〈0. 05）. As to the AKI staging in control group,there was no significantly difference in the NI and NII between survival and death patients（P〈0. 05）,while in NIII,the survival patients were significantly lower than that of the death patients（P〈0. 01）. The significant difference on AKI NI and AKI NIII in observation group were seen between survival and death patients（P〈0. 01）. The incidence of complications rate in survival patients was much less than that of death patients in both two groups（P〈0. 01）. There was no significantly difference in the treatment time interval of chronic obstructive pneumonia between survival and death patients in observation group（P〈0. 05）. However,the time interval from entering ICU to carrying CRRT in survival patients was significantly shorter than that of death patients（P〈0. 01）. Conclusion CRRT could effectively remove inflammatory factor in the treatment of patients with sepsis acute kidney injury,reduce the mortality and maintain the relative stability of internal environment. The early CRRT application might improve the 30-days survival rate of patients with sepsis acute kidney injury.

文章關(guān)鍵詞：

Keyword：:CRRT Sepsis Acute kidney injury Treatment Clinical study

  本文關(guān)鍵詞：CRRT在膿毒血癥急性腎損傷患者救治中的臨床研究，由筆耕文化傳播整理發(fā)布。