本文選題：腦外傷 + 昏迷��； 參考：《中國康復理論與實踐》2016年04期

【摘要】：目的探討迷走神經(jīng)電刺激對腦外傷昏迷大鼠促醒作用及對前額葉皮質5-HT2A受體表達的影響。方法將72只Sprague-Dawley大鼠隨機分為空白對照組、假刺激組、刺激組和拮抗劑組,每組18只。應用自由落體撞擊法建立腦外傷昏迷模型。拮抗劑組注入OXR1受體拮抗劑SB334867,采用迷走神經(jīng)電刺激治療刺激組和拮抗劑組。觀察其行為學變化,并用免疫組織化學技術檢測各組大鼠前額葉皮質5-HT2A受體表達的影響。結果刺激組12只蘇醒,拮抗劑組9只蘇醒,假刺激組4只蘇醒。5-HT2A受體含量從低到高依次為:空白對照組、拮抗劑組、假刺激組、刺激組(χ~2=11.464,P=0.009)。結論迷走神經(jīng)電刺激可提高腦外傷昏迷大鼠意識狀態(tài),其機制可能與上調5-HT2A受體有關。
[Abstract]:Objective to investigate the effects of vagal electrical stimulation on 5-HT2A receptor expression in the prefrontal cortex of coma rats after brain injury. Methods Seventy-two Sprague-Dawley rats were randomly divided into control group, sham stimulation group, stimulation group and antagonist group with 18 rats in each group. A coma model of traumatic brain injury was established by free fall impact. OXR1 receptor antagonist SB334867 was injected into the antagonist group, and the vagus nerve stimulation group and the antagonist group were used. The behavioral changes were observed and the expression of 5-HT2A receptor in prefrontal cortex of rats in each group was detected by immunohistochemistry. Results 12 rats in the stimulation group, 9 in the antagonist group and 4 in the sham stimulation group were awakened from low to high: blank control group, antagonist group, sham stimulation group, stimulation group (蠂 ~ 2 + 2) 11.464 (P 0.009). Conclusion vagal electrical stimulation can improve the conscious state of coma rats with brain injury, and its mechanism may be related to the up-regulation of 5-HT2A receptor.
【作者單位】： 南昌大學第一附屬醫(yī)院康復醫(yī)學科;
【基金】：國家自然科學基金項目(No.81260295) 江西省研究生創(chuàng)新基金(No.YC2015-S090)
【分類號】：R651.15

【相似文獻】

相關期刊論文 前6條

1 張建梁;何敏賢;張宏啟;;迷走神經(jīng)電刺激治療癲癇的現(xiàn)狀與展望[J];中國病理生理雜志;2005年11期

2 于亭亭;陳霞;李昌陽;高興亞;范志寧;;長期迷走神經(jīng)電刺激對肥胖鼠攝食和體重的影響[J];中國微創(chuàng)外科雜志;2012年01期

3 白熙;張國君;;迷走神經(jīng)電刺激參數(shù)調控的研究進展[J];中國微侵襲神經(jīng)外科雜志;2013年12期

4 周建鵬;周洪語;;迷走神經(jīng)電刺激治療難治性癲沲的作用機制與臨床應用[J];中國微侵襲神經(jīng)外科雜志;2011年11期

5 徐紀文,羅其中;迷走神經(jīng)電刺激與癲癇[J];上海醫(yī)學;2000年04期

6 ;[J];;年期

，

本文編號：1866109