本文選題：腱糖蛋白C + 急性心肌梗死��； 參考：《廣西醫(yī)科大學》2013年碩士論文

【摘要】：目的：觀察急性心肌梗死患者入院后腱糖蛋白C (Tenaseins-C, TN-C)血清中濃度的變化與左室重構的關系。 方法：收集60例AMI患者以及19例診斷明確UA患者與20例體檢正常對照者。用ELISA法測定急診送入CCU的患者即刻血清中TN-C、發(fā)病后第3天、第7天血清中TN-C濃度水平變化及入院CRP、cTn-T的峰值。首次發(fā)病住院心臟彩超及3個月后隨訪復查,測定EF、FS、LVEDV、LVESV作為左心室容積指標。并根據(jù)左心室舒張末期容積指數(shù)LVEDVI (LVEDV/體表面積BSA)作為研究觀察指標,LVEDVI≤20%作為非重構組,LVEDVI20%作為重構組。用SPSS13.0統(tǒng)計軟件包進行統(tǒng)計學分析。結果：(1)AMI組患者入院后即刻TN-C濃度明顯高于正常對照組(P0.05),同時也明顯高于UA組(P0.05),AMI患者第3天血清中TN-C濃度在高于入院即測(P0.05),也明顯高于第7天測定濃度(P0.05)。(2)第3天血清TN-C濃度與CRP呈正相關(r=0.310,P0.05),與cTn-T呈正相關(r=0.820,P0.05)。(3)AMI組TN-C峰值濃度與心梗急性期心臟彩超測定EF值呈負相關(r=-0.820,P0.05),TN-C濃度峰值與FS呈負相關(r=-0.277,P0.05)。(4)隨訪左心室重構發(fā)生率32.69%,經pearson相關性分析提示TN-C峰值濃度與重構組LVEDVI呈正相關(r=0.839,P0.05),與ΔLVEDVI成正相關 (r=0.761,P0.05),logistics回歸分析及ROC曲線分析顯示TN-C與左心室重構相關。 結論：AMI患者急性期TN-C濃度水平明顯高于UA患者及正常對照組,心梗發(fā)生后第3天血清TN-C濃度可出現(xiàn)較高濃度表達,與CRP濃度、cTn-T呈正相關,與心臟射血分數(shù)EF、左室短軸縮短率FS呈負相關。AMI患者血清TN-C峰值水平與心室重構可能密切相關,具有一定的臨床判斷意義。
[Abstract]:Aim: to observe the relationship between the serum concentration of tenaseins-C (TN-C) and left ventricular remodeling in patients with acute myocardial infarction (AMI). Methods: 60 patients with AMI, 19 patients with definite UA and 20 normal controls were collected. The serum TN-Cwas measured by ELISA method in the patients who were admitted to CCU immediately. The serum TN-C level and the peak value of CRPcTn-T were measured on the 3rd and 7th day after the onset of the disease. Echocardiography was performed for the first time and followed up for 3 months to determine the left ventricular volume (LVV) of EFFSV DVV and LVESV. The left ventricular end-diastolic volume index (LVEDVI) was used as the index of LVEDVI 鈮，

本文編號：1820590