發(fā)布時(shí)間：2018-03-23 13:35

  本文選題：腦心通膠囊　切入點(diǎn)：經(jīng)皮冠狀動(dòng)脈介入治療　出處：《中國(guó)藥房》2016年27期

【摘要】：目的:觀(guān)察腦心通膠囊對(duì)急性心肌梗死(AMI)患者行經(jīng)皮冠狀動(dòng)脈介入治療(PCI)后心肌灌注和血小板活化功能的影響。方法:100例AMI患者采用平行隨機(jī)抽樣法分為對(duì)照組與觀(guān)察組,每組50例。對(duì)照組患者給予常規(guī)PCI治療,術(shù)前嚼服阿司匹林300 mg+氯吡格雷300 mg,術(shù)后服用阿司匹林100 mg/d+氯吡格雷75 mg/d。觀(guān)察組患者在對(duì)照組治療基礎(chǔ)上(支架釋放后)加服腦心通膠囊2~4粒,每日3次。兩組療程均為7 d,觀(guān)察期為1個(gè)月。觀(guān)察并比較兩組患者PCI后15 min心肌灌注分級(jí)(TMPG)情況,治療前后的血小板活化功能指標(biāo)[CD62P、CD63及單核細(xì)胞血小板聚集體(MPA)陽(yáng)性表達(dá)率],觀(guān)察期內(nèi)主要心血管事件(MACE)和并發(fā)癥以及不良反應(yīng)發(fā)生情況。結(jié)果:治療后,觀(guān)察組患者TMPG灌注3級(jí)例數(shù)占比顯著高于對(duì)照組,MACE發(fā)生率顯著低于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05);兩組患者并發(fā)癥發(fā)生率和不良反應(yīng)發(fā)生率比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。治療前,兩組患者CD62P、CD63、MPA陽(yáng)性表達(dá)率比較差異無(wú)統(tǒng)計(jì)學(xué)意義(P0.05);治療后,兩組患者CD62P、CD63、MPA陽(yáng)性表達(dá)率顯著低于同組治療前,且觀(guān)察組低于對(duì)照組,差異均有統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論:腦心通膠囊可以迅速提高AMI患者PCI后血小板活化功能,改善TMPG灌注情況,降低MACE發(fā)生率,且不增加并發(fā)癥發(fā)生率,安全性較好。
[Abstract]:Objective: to observe the effect of Naoxintong capsule on myocardial perfusion and platelet activation after percutaneous coronary intervention (PCI) in patients with acute myocardial infarction (AMI). 50 cases in each group. The patients in the control group were treated with routine PCI. The patients in the observation group were treated with aspirin 300mg clopidogrel 300mg before operation and 75 mg / d of clopidogrel for 100 mg/d postoperatively. The patients in the observation group were treated with Naoxintong capsule (2g / d) on the basis of the treatment of the control group (after the release of the stent). Three times a day. The course of treatment was 7 days and the observation period was 1 month. The myocardial perfusion grade of 15 min after PCI was observed and compared between the two groups. The platelet activation function before and after treatment [positive expression rate of CD62PnCD63 and monocyte platelet aggregates (MPAs)], major cardiovascular events (MACEs), complications and adverse reactions during the period of treatment were observed. The incidence of TMPG perfusion grade 3 in the observation group was significantly higher than that in the control group (P 0.05), and there was no significant difference between the two groups in the incidence of complications and adverse reactions (P 0.05). There was no significant difference in the positive expression rate of CD62PfU CD63MPA between the two groups. After treatment, the positive expression rate of CD62Pnc-CD63MPA in the two groups was significantly lower than that in the same group and the observation group was lower than that in the control group, and the positive expression rate of CD63MPA in the observation group was lower than that in the control group. Conclusion: Naoxintong capsule can rapidly improve platelet activation function after PCI, improve TMPG perfusion, reduce the incidence of MACE, and do not increase the incidence of complications in patients with AMI.
【作者單位】： 濰坊市益都中心醫(yī)院燒傷兒外科;濰坊市益都中心醫(yī)院介入治療科;
【分類(lèi)號(hào)】：R542.22

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