本文選題：腦梗死　切入點：急性腦梗死　出處：《山東醫(yī)藥》2016年27期 　論文類型：期刊論文

【摘要】：目的分析血清鐵調(diào)素25(Hepc25)、鐵蛋白(PF)和轉(zhuǎn)鐵蛋白(TRF)對老年急性腦梗死患者早期病情及其預(yù)后的評估價值。方法 227例老年急性腦梗死患者(觀察組,其中輕型73例、中型79例和重型75例)分別于發(fā)病24、48、72 h及7、14、28 d時檢測血清Hepc25、PF和TRF。80例老年健康體檢者(對照組)檢測血清Hepc25、PF和TRF。比較發(fā)病24、48、72 h及7、14、28 d時觀察組和對照組血清Hepc25、PF和TRF。發(fā)病28 d時判定觀察組預(yù)后。分析老年急性腦梗死患者血清Hepc25、PF、TRF與神經(jīng)功能缺損程度及預(yù)后的關(guān)系。結(jié)果發(fā)病24、48、72 h及7、14、28 d時觀察組血清Hec25和PF水平均高于對照組,TRF水平均低于對照組(P均0.05);發(fā)病24、48、72 h及7、14、28 d時,隨NIHSS評分升高,觀察組血清Hepc25、PF升高,TRF水平降低(P均0.05)。觀察組分為基本痊愈42例、顯著進(jìn)步84例、進(jìn)步67例和無變化34例。發(fā)病24、48、72 h及7、14、28 d時,觀察組基本痊愈、顯著進(jìn)步和進(jìn)步者血清Hepc25、PF均低于,TRF水平高于無變化者(P均0.05);發(fā)病24 h時血清Hepc25、PF均與NIHSS呈正相關(guān)(r=0.704和0.653,P均0.05),TRF與NIHSS呈負(fù)相關(guān)(r=-0.614,P0.05);發(fā)病28 d時血清Hepc25、PF均與患者預(yù)后呈負(fù)相關(guān)(r=-0.692和-0.517,P均0.05),TRF與患者預(yù)后呈正相關(guān)(r=0.635,P0.05)。結(jié)論老年急性腦梗死患者存在血清Hepc25、PF、TRF動態(tài)變化。血清Hepc25、PF、TRF動態(tài)變化可用于老年急性腦梗死患者早期病情預(yù)后評估。
[Abstract]:Objective to analyze the value of serum ferritin 25 Hepc25 (PFF) and transferrin (TRFs) in evaluating the early state of illness and prognosis of elderly patients with acute cerebral infarction. Methods 227 elderly patients with acute cerebral infarction (observation group, 73 patients with mild cerebral infarction) were included in the study group. The serum Hepc25PF and TRFs were detected in 79 cases of moderate and 75 cases of severe disease at 24 hours and 28 days after onset, respectively. The serum Hepc25PF and TRFs of the observation group and the control group were compared at 24: 872 hours and 714 days after the onset of the disease, and the serum Hepc25PF and TRFs of the control group were compared with those of the control group at 24: 4872 hours and 714 days after the onset of the disease, and the serum Hepc25PF and TRFs of the control group were compared with those of the control group. The prognosis of the observation group was evaluated at 28 days after onset, and the relationship between the serum Hepc25 PFFRF and the degree of neurological function defect and prognosis was analyzed. Results the serum Hec25 and PF levels in the observation group were higher than those in the control group at 24: 48 hours and 714 days after onset. The levels were lower than those in the control group (P < 0.05), and at the onset of the disease (24 ~ 48 ~ 72h) and at ~ (714) ~ (28) d, respectively. With the increase of NIHSS score, the serum levels of Hepc25PF increased and the levels of TRF decreased (P < 0.05). In the observation group, 42 cases were basically cured, 84 cases improved significantly, 67 cases improved and 34 cases showed no change. The serum levels of Hepc25PF were significantly lower than those of TRF in patients with significant progress and progression than those without change (P = 0.05), and were positively correlated with NIHSS at 24 h after onset. There was a negative correlation between serum Hepc25PF and NIHSS, and a negative correlation between serum Hepc25PF and NIHSS, and a negative correlation between serum Hepc25PF and the prognosis of the patients at 28 days after onset. There was a positive correlation between TRF and prognosis in patients with acute cerebral infarction. Conclusion there are dynamic changes of serum Hepc25 PFTRF in elderly patients with acute cerebral infarction, and the dynamic changes of serum Hepc25 + PFN TRF can be used to evaluate the early prognosis of elderly patients with acute cerebral infarction.
【作者單位】： 山東大學(xué)附屬第二醫(yī)院;山東省婦幼保健院;
【基金】：河南省科技計劃項目(142102310417)
【分類號】：R743.3

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