發(fā)布時間：2018-02-12 11:33

  本文關(guān)鍵詞： 膿毒癥 免疫功能 升降散 臨床療效　出處：《免疫學(xué)雜志》2017年11期 　論文類型：期刊論文

【摘要】：目的評估中藥升降散對糾正膿毒癥免疫功能紊亂和改善患者癥狀的臨床療效。方法選取2014年6月至2016年6月在寧夏回族自治區(qū)工人醫(yī)院就診的53例膿毒癥患者作為研究對象,根據(jù)住院號的奇偶性分為觀察組(n=28)和對照組(n=25)。2組均予以西醫(yī)常規(guī)治療,觀察組在此基礎(chǔ)上加用升降散治療,對照組則相應(yīng)給予生理鹽水。觀察2組在治療后第1、3和7天的免疫指標變化和記錄28天內(nèi)的臨床結(jié)局。結(jié)果與對照組相比,觀察組患者在給藥第7天時的CD4~+T細胞計數(shù)、CD8~+T細胞計數(shù)和m HLADR表達顯著增加(P0.05)。進一步評估單核細胞功能結(jié)果顯示,與對照組相比,觀察組患者在給藥第3天和第7天的單核細胞分泌的IL-6和TNF-α水平顯著提高(P0.05),而在第7天的IL-10水平顯著降低(P0.05)。觀察組患者的ICU住院時間、APACHE II評分、Marshall評分和血管加壓素使用時間均顯著低于對照組(P0.05)。結(jié)論升降散可以糾正膿毒癥患者的細胞免疫,并且可作為一個有希望的膿毒癥輔助治療方案。
[Abstract]:Objective to evaluate the clinical effect of Shengsheng Powder on correcting the immune dysfunction and improving the symptoms of sepsis. Methods 53 patients with sepsis were selected from June 2014 to June 2016 in the workers' hospital of Ningxia Hui Autonomous region. According to the parity of hospital number, the patients in the observation group were divided into two groups: the observation group and the control group were treated with routine western medicine. The control group was given normal saline accordingly. The changes of immune indexes and clinical outcome within 28 days after treatment were observed and compared with those in the control group. The CD4 ~ T cell count and the expression of m HLADR were significantly increased in the observation group on the 7th day after administration. Further evaluation of monocyte function showed that compared with the control group, the expression of m HLADR and CD8T cell were significantly increased in the observation group. The levels of IL-6 and TNF- 偽 secreted by monocytes on the 3rd and 7th day of administration in the observation group were significantly higher than those in the control group, while the level of IL-10 was significantly decreased on the 7th day. The ICU hospitalization time of the patients in the observation group was evaluated by Apache II score and vascular pressure. Conclusion Shengsheng Powder can correct the cellular immunity of sepsis patients. It can be used as a promising adjuvant therapy for sepsis.
【作者單位】： 寧夏回族自治區(qū)工人療養(yǎng)院普外科;天津市人民醫(yī)院科普外科;
【分類號】：R459.7

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