本文關(guān)鍵詞： 急性心力衰竭 CA NT-proBNP 預(yù)后 死亡率　出處：《中國現(xiàn)代醫(yī)學(xué)雜志》2016年24期 　論文類型：期刊論文

【摘要】：目的對聯(lián)合檢測血清糖類抗原CA125(CA125)和N末端腦鈉肽原(NT-proBNP)水平用于預(yù)測急性心力衰竭患者預(yù)后的價值進行評估。方法納入68例急性左心衰竭發(fā)作24 h之內(nèi)入院的患者,檢測血清NT-proBNP和CA125水平,根據(jù)患者出院6個月時的預(yù)后,分為死亡(6個月之內(nèi)死亡)、再發(fā)作(存活,有急性左心衰竭再發(fā)作)和穩(wěn)定(存活且無心力衰竭再發(fā)作)組,對單獨和聯(lián)合應(yīng)用NT-proBNP和CA125水平用于預(yù)測患者預(yù)后的價值進行分析。結(jié)果不同分組患者的CA125水平差異有統(tǒng)計學(xué)意義(P=0.013),再發(fā)作組和死亡組患者的血清CA125水平高于穩(wěn)定組,差異有統(tǒng)計學(xué)意義(P=0.004和0.030),CA125和NT-proBNP均為陽性者的死亡風(fēng)險高于其他患者。結(jié)論聯(lián)合檢測血清CA125和NT-proBNP水平,可以準確預(yù)測急性心力衰竭患者出院6個月之內(nèi)的死亡風(fēng)險。
[Abstract]:Objective to detect serum carbohydrate antigen CA125 (CA125) and N-terminal brain natriuretic peptide (NT-proBNPs). Methods 68 patients with acute left heart failure were admitted within 24 hours. The serum levels of NT-proBNP and CA125 were measured. According to the prognosis of the patient at 6 months after discharge, the patients were divided into death (death within 6 months, reattack) (survival). The group with acute left ventricular failure (ARF) and stable (survival with no recurrence of heart failure). The value of NT-proBNP and CA125 levels in predicting the prognosis of patients was analyzed. Results there were significant differences in CA125 levels among different groups of patients (. P0. 013). The serum CA125 levels in patients with recurrent attack and death were significantly higher than those in stable group (P 0. 004 and 0. 030). The risk of death in both CA125 and NT-proBNP positive patients was higher than that in other patients. Conclusion Serum CA125 and NT-proBNP levels are detected in combination. It can accurately predict the risk of death in patients with acute heart failure within 6 months of discharge.
【作者單位】： 北京大學(xué)國際醫(yī)院;首都醫(yī)科大學(xué)宣武醫(yī)院;
【分類號】：R541.6
【正文快照】： 研究表明,糖類抗原CA125(carbohydrate anti-gen-125,CA125)除了作為臨床診斷卵巢癌的標志性抗原之外,還可作為心功能不全及心臟移植患者血流動力學(xué)和心功能改變的指標[1],急性心力衰竭發(fā)表3 CA125、NT-pro BNP不同組患者的死亡風(fēng)險組別例數(shù)死亡/存活/例死亡率/%CA125陽性NT-p

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