【摘要】：目的:對(duì)慢性HBV感染者符合病理學(xué)分期為S3和S4期者的臨床資料進(jìn)行對(duì)比性研究,以探討纖維化程度與臨床指標(biāo)的關(guān)系。 方法:對(duì)292例慢性HBV感染者肝活檢符合病理學(xué)分期為S3和S4期者的臨床資料進(jìn)行回顧性分析，比較不同年齡,病程以及HBVDNA水平與病理學(xué)診斷的關(guān)系，同時(shí)還比較病理學(xué)診斷與患者病史，臨床生化檢測(cè)值及影像學(xué)指標(biāo)之間的關(guān)系。 結(jié)果:292例患者中病理診斷為S3期有140（47.9%）例，S4期為152（52.1%）例。從年齡分布來(lái)㩳40歲組中S3期比例高于S4期，≥40歲組中S3期比例低于S4期。從ALT水平來(lái)看，在S4期中，ALT水平在1~2倍正常值組比例最高，而在S3期中，ALT水平≤1.0倍正常值組比例最高。進(jìn)一步多因素的分析顯示：病程，，年齡，飲酒史，ALT，HBVDNA水平以及彩超檢查肝表面光滑程度都與肝纖維化的進(jìn)展有關(guān)。 結(jié)論:1.病程大于5年以上且ALT水平介于1~2倍正常值的患者，進(jìn)行肝活檢的臨床意義更大。2.對(duì)于肝纖維化治療前的評(píng)估應(yīng)進(jìn)行多因素分析，而非僅依據(jù)ALT水平。
[Abstract]:Aim: to compare the clinical data of patients with chronic HBV infection in accordance with the pathological stages S3 and S4 in order to explore the relationship between the degree of fibrosis and clinical indexes. Methods: the clinical data of liver biopsy from 292 patients with chronic HBV infection were retrospectively analyzed, and the relationship among different age, course of disease, HBVDNA level and pathological diagnosis was compared, and the pathological stage was S _ 3 and S _ 4 stages of liver biopsy in patients with chronic HBV infection were analyzed retrospectively. At the same time, the relationship between pathological diagnosis and patient history, clinical biochemical value and imaging index was also compared. Results: in 292 cases, 140 (47.9%) cases were diagnosed as S3 stage and 152 (52.1%) cases were at S4 stage. According to the age distribution, the proportion of S _ 3 stage in 40-year-old group was higher than that in S-4 stage, and that in 鈮

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