【摘要】：目的了解河南省開封市育齡婦女與嬰兒麻疹抗體水平,探尋高發(fā)人群麻疹免疫預(yù)防策略。方法采用酶聯(lián)免疫吸附試驗(yàn)(ELISA)對(duì)開封市育齡婦女與嬰兒進(jìn)行麻疹I(lǐng)gG抗體水平血清學(xué)檢測(cè)和統(tǒng)計(jì)學(xué)分析。結(jié)果 740名嬰兒中麻疹I(lǐng)gG抗體陽性率為45.00%,抗體保護(hù)率為22.57%,抗體幾何平均濃度(GMC)為91.34IU/ml。8~11月齡嬰兒麻疹抗體GMC高于0~7月齡嬰兒(t=5.16,P0.01)。0~7月齡嬰兒麻疹抗體陽性率隨著月齡增大而降低(χ~2=136.51,P0.01),7月齡組嬰兒抗體水平最低,GMC為17.41 IU/ml;而8~11月齡嬰兒抗體陽性率隨著月齡的增長而上升(χ~2=49.53,P0.01);有含麻疹成分疫苗(MCV)免疫史嬰兒抗體水平高于無免疫史(t=9.24,P0.01)。249名育齡婦女麻疹抗體陽性率為94.38%,抗體保護(hù)率為50.20%,GMC為694.54IU/ml;29~35歲組抗體GMC高于18~28歲組(t=5.47,P0.01);有免疫史者抗體GMC低于無免疫史者(t=6.76,P0.01);有患病史者抗體GMC高于無患病史者(t=13.42,P0.01)。結(jié)論育齡婦女、嬰兒麻疹抗體水平低,需通過提高首劑MCV及時(shí)接種率、實(shí)時(shí)調(diào)整首劑MCV接種月齡及育齡婦女接種等綜合免疫預(yù)防措施來推進(jìn)消除麻疹工作。
[Abstract]:Objective to investigate the measles antibody level among childbearing women and infants in Kaifeng City, Henan Province, and to explore the strategy of measles immunization prevention in high incidence population. Methods Elisa (ELISA) was used to detect measles IgG antibody level in childbearing women and infants in Kaifeng city. Results among 740 infants, the positive rate of measles IgG antibody was 45.00, and the protective rate of measles antibody was 22.57. The geometric mean concentration of (GMC) of measles antibody GMC of 91.34IU/ml.8~11 month-old infants was higher than that of 0-7-month-old infants (t = 5.16). The positive rate of measles antibody in 7-month-old infants decreased with the increase of age (蠂 ~ (2) 136.51 / P0.01). The antibody level of infants in 7-month-old group was the lowest (GMC = 17.41 IU/ml;). However, the positive rate of antibody increased with the increase of age (蠂 ~ 2 + 49.53 / P0.01). The antibody level of infants immunized with measles vaccine was higher than that without immunization history (t 9.24 P0.01). The positive rate of measles antibody in 249 women of childbearing age was 94.38, and the protective rate of antibody was 50.20%. The antibody GMC in the age group of 29 ~ 35 years was higher than that in the group of 18 ~ 28 years old (t = 5.47, P0.01), the antibody GMC in the group with immunological history was lower than that in the group without immune history (t = 6.76, P 0.01), and the antibody GMC in those with a history of disease was higher than that in the group without a history of disease (t = 13.42, P 0.01). Conclusion the level of measles antibody in infants of childbearing age women is low. It is necessary to improve the vaccination rate of first dose of MCV in time and to adjust the first dose of MCV vaccination in real time to promote the work of eliminating measles by means of comprehensive immunization prevention measures such as inoculation of the first dose of MCV and inoculation of women of childbearing age.
【作者單位】： 河南省開封市疾病預(yù)防控制中心;河南大學(xué)第一附屬醫(yī)院;
【基金】：開封市科技發(fā)展計(jì)劃項(xiàng)目(項(xiàng)目號(hào)130332)
【分類號(hào)】：R511.1

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