本文選題：結(jié)核病 + 乙型肝炎病毒�。� 參考：《南華大學(xué)》2014年碩士論文

【摘要】：目的： 了解邵陽地區(qū)結(jié)核�。═uberculosis，TB）患者感染乙型肝炎病毒（Hepatitis B virus，HBV）、丙型肝炎病毒（Hepatitis C virus，HCV）、人類免疫缺陷病毒（Human Immunodeficiency Virus，HIV）和梅毒螺旋體（TreponemaPallidun，TP）的狀況及特征，為本地區(qū)TB的控制和治療方案的制定提供實驗依據(jù)。 方法： 收集2009年1月~2012年12月邵陽地區(qū)2947例TB患者血清，用酶聯(lián)免疫吸附試驗（Enzyme-linked immunosorbent assay，ELISA）和乳膠層析法檢測HBV“兩對半”；ELISA法初篩檢測HCV抗體，再用RFQ-PCR法進行確證；ELISA和膠體金法檢測HIV抗體進行初篩，用Western blot確證。收集2009年1月~2013年12月邵陽地區(qū)3545例TB患者血清，用ELISA初篩后再用梅毒螺旋體明膠凝集試驗（Treponema pallidum particle agglutination，TPPA）檢測TP特異性抗體。同時收集患者臨床資料行流行病學(xué)調(diào)查，分析其感染模式。 結(jié)果： 1.2947例TB患者中共檢出感染者573例，其中HBV、HCV和HIV感染者分別為535（18.15%）、69（2.34%）和3例（1.02%）；檢出HBV＆HCV、HBV＆HIV、HBV＆HIV＆HCV三種合并感染模式。 2.3545例TB患者中共檢出TP抗體陽性患者106例（2.99%），，檢出TP＆HBV、TP＆HCV、TP＆HBV＆HIV三種合并感染模式。 3.不同性別、年齡、職業(yè)TB患者HBV、HCV、HIV、TP感染率有顯著性差異。21~50歲的TB患者合并HBV和TP感染率最高；41~60歲男性自由（不詳）職業(yè)TB患者者更易合并HCV感染。2009~2013年，TP感染率總體呈逐年上升趨勢。 結(jié)論： 1．邵陽地區(qū)TB患者易合并HBV感染，并有HIV感染和流行風(fēng)險。 2．邵陽地區(qū)21~50歲的TB患者易合并HBV和TP感染；41~60歲男性自由職業(yè)TB患者更易合并HCV感染。
[Abstract]:Objective: To understand the status and characteristics of hepatitis B virus (HBV), hepatitis C virus (hepatitis C virus), human immunodeficiency virus (Immunodeficiency) and Treponema pallidunus (Treponema pallidunus) in patients with tuberculosis (TB) in Shaoyang area, To provide experimental basis for TB control and treatment in this area. Methods: From January 2009 to December 2012, serum samples of 2947 TB patients in Shaoyang area were collected. Enzyme-linked immunosorbent assayer Elisa (Elisa) and latex chromatography were used to detect HCV antibody in the sera of 2947 TB patients in Shaoyang area from January 2009 to December 2012. Then RFQ-PCR Elisa and colloidal gold assay were used to detect HIV antibody. Western blot was used to identify the antibody. The serum samples of 3545 TB patients in Shaoyang from January 2009 to December 2013 were collected. The TP specific antibody was detected by Treponema pallidum particle agglutination test (Treponema pallidum particle agglutination) after primary screening with ELISA. At the same time, the clinical data were collected and epidemiological investigation was carried out to analyze the infection pattern. Results: A total of 573 cases were detected in 1.2947 patients with TB, including 535 / 18.15535 / 18.15C / C / 69 / 2 / 34 and 3 / 1.02 / 2, respectively, and three co-infection modes of HBV and HCV and HIV / HCV were detected. A total of 2.3545 TB patients were found to have TP antibody positive, and three co-infection modes of TP & HBV / TP and HBV / HBV / HIV were detected. 3. Different sex, age, There was significant difference in the infection rate of HIV / HBV in occupational TB patients. The highest rate of HBV infection was found in the TB patients aged 21 ~ 50 years and the highest rate of TP infection was found in males aged 41 ~ 60 years. The rate of TP infection was increased year by year in the patients with occupational TB patients who were more likely to be associated with HCV infection. From 2009 to 2013, the TP infection rate increased year by year. Conclusion: 1. TB patients in Shaoyang area are prone to HBV infection and risk of HIV infection and epidemic. 2. TB patients aged 21 ~ 50 years in Shaoyang area were more likely to be associated with HBV and TP infection. Male freelance TB patients aged 60 years old were more likely to be associated with HCV infection.
【學(xué)位授予單位】：南華大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R52

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