106例復(fù)治痰涂片陽(yáng)性肺結(jié)核患者的痰培養(yǎng)及耐藥性分析
本文選題:涂陽(yáng)肺結(jié)核 + 復(fù)治 ; 參考:《中國(guó)衛(wèi)生檢驗(yàn)雜志》2016年22期
【摘要】:目的收集天津市結(jié)核病控制中心首次治療失敗的結(jié)核病患者的耐藥情況,為復(fù)發(fā)患者制定合理化方案提供參考。方法納入者從2010年1月-2014年12月選取有痰培養(yǎng)陽(yáng)性結(jié)果以及藥物敏感性試驗(yàn)結(jié)果的患者。所有納入患者的痰培養(yǎng)結(jié)果分別進(jìn)行6種抗結(jié)核藥物敏感性檢測(cè)。結(jié)果 106例復(fù)治痰涂片陽(yáng)性肺結(jié)核患者中出現(xiàn)18例痰培養(yǎng)陰性,其余88例痰培養(yǎng)陽(yáng)性中,出現(xiàn)耐藥情況55例,耐藥者占51.89%,單耐藥率為17.05%,多耐藥率為5.68%,耐多藥率為14.77%,耐多藥以耐3種~4種藥物的患者較多,共11例,占全部耐多藥患者的84.62%。結(jié)論復(fù)治痰涂片陽(yáng)性的肺結(jié)核患者耐藥率及耐多藥率較高,且耐多藥中耐3種以上藥物居多,應(yīng)重視廣泛耐藥情況的發(fā)生。當(dāng)前的標(biāo)準(zhǔn)化復(fù)治肺結(jié)核方案患者應(yīng)及時(shí)關(guān)注痰培養(yǎng)及藥敏試驗(yàn)結(jié)果,以指導(dǎo)下一步治療。
[Abstract]:Objective to collect the drug resistance of tuberculosis patients who failed in the first treatment in Tianjin TB Control Center, and to provide reference for the rational plan of relapse patients. Methods patients with positive sputum culture and drug sensitivity test were selected from January 2010 to December 2014. The results of sputum culture in all patients were tested for the sensitivity of 6 anti-tuberculosis drugs. Results among 106 patients with re-treated sputum smear positive pulmonary tuberculosis, there were 18 cases with negative sputum culture, and 55 cases with drug resistance among the remaining 88 cases of sputum culture positive. The drug resistance rate was 51.89, the rate of single drug resistance was 17.05, the rate of multi-drug resistance was 5.68, the rate of multi-drug resistance was 14.777.The number of patients with multi-drug resistance to three or four drugs was 11, accounting for 84.62% of all patients with multi-drug resistance. Conclusion the rate of drug resistance and multidrug resistance of tuberculosis patients with positive sputum smear is higher, and more than 3 kinds of drugs are more resistant in multidrug resistance, so we should pay attention to the occurrence of extensive drug resistance. The current standardized relapse regimen should pay attention to the results of sputum culture and drug sensitivity test in order to guide the next treatment.
【作者單位】: 天津市結(jié)核病控制中心;天津醫(yī)科大學(xué)公共衛(wèi)生學(xué)院;
【分類號(hào)】:R52
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