本文選題：肝炎 + 乙型��； 參考：《中國臨床醫(yī)學(xué)影像雜志》2015年06期

【摘要】：目的:應(yīng)用實時剪切波彈性成像技術(shù)測定慢性乙型病毒肝炎患者肝臟楊氏模量值,評價替比夫定對慢性乙型病毒肝炎肝纖維化治療效果。方法:選擇慢性乙型病毒肝炎肝纖維化患者80名(均在治療前進行肝活檢),A組(S0,S1)22例,B組(S2,S3)40例,C組(S4)18例,所有患者進行替比夫定藥物治療,分別在治療前和治療后24周進行實時剪切波彈性成像測量肝臟楊氏模量值和血清學(xué)檢查,包括透明質(zhì)酸(Hyaluronic acid,HA)、層黏蛋白(LN)、三型前膠原N端肽(PⅢPN-P)、Ⅳ型膠原(CL-Ⅳ),比較各參數(shù)治療前后變化。結(jié)果 :所有A、B、C 3組血清學(xué)指標HA、LN、PⅢPN-P、CL-Ⅳ治療24周后均較治療前降低,差異均有統(tǒng)計學(xué)意義(P0.05),而所有A、B、C 3組實時剪切波彈性測量肝臟楊氏模量值治療后均比治療前降低,差異均有統(tǒng)計學(xué)意義(P0.05)。治療前與治療后實時剪切波彈性測量肝臟楊氏模量值均為A組B組C組。結(jié)論:實時剪切波彈性成像測量肝臟彈性模量值可以用來對替比夫定治療慢性乙型肝炎療效進行評估。
[Abstract]:Aim: to evaluate the therapeutic effect of tibivudine on liver fibrosis of chronic hepatitis B virus by measuring the Young's modulus of liver with real time shear wave elastography. Methods: 80 patients with chronic hepatitis B hepatitis liver fibrosis were selected. All of them were treated with tibivudine in group A (22 cases of S0 S1) and group B (40 cases of S2OS3). All the patients were treated with tibivudine, and all of them were treated with tibivudine. Real time shear wave elastography was performed before and 24 weeks after treatment to measure the Young's modulus of liver and serological examination. It included hyaluronic acididine, laminin (LNN), type 3 procollagen N-terminal peptide (P 鈪，

本文編號：1884115