本文選題：幽門螺桿菌　切入點(diǎn)：三聯(lián)療法　出處：《石河子大學(xué)》2013年碩士論文　論文類型：學(xué)位論文

【摘要】：目的：本實(shí)驗(yàn)主要通過臨床觀察為期10天的標(biāo)準(zhǔn)劑量抗生素聯(lián)合抑酸藥與小劑量抗生素聯(lián)合抑酸藥治療幽門螺桿菌，來評(píng)估標(biāo)準(zhǔn)劑量與小劑量抗生素聯(lián)合抑酸藥治療方案治療幽門螺桿菌的根治率、不良反應(yīng)、依從性、成本的影響差異。 方法：選擇我院2011年6月至2012年6月幽門螺桿菌感染患者108例，將其隨機(jī)分為兩組：A組(標(biāo)準(zhǔn)劑量)，蘭索拉唑(15mg)，阿莫西林(1g)，克拉霉素(500mg)，一日兩次，療程10天；B組(小劑量)，，蘭索拉唑(15mg)一日兩次，阿莫西林(500mg)，克拉霉素(250mg)，一日三次，療程10天。停藥至少4周后或停用抑酸藥至少2周后行尿素呼氣試驗(yàn)(UBT)。對(duì)整個(gè)治療期間的依從性及不良反應(yīng)、成本進(jìn)行評(píng)估。 結(jié)果：108例幽門螺桿菌感染患者(男54人，女54人；平均年齡51.6±12.2歲)，隨機(jī)分為A組(標(biāo)準(zhǔn)劑量組)；B組(小劑量組)。 1．經(jīng)治療后：ITT分析，A組、B組的根除率分別是83.3％(45/54)、81.5％(44/54)，差異無統(tǒng)計(jì)學(xué)意義(P=1.00)。PP分析，A組、B組的根除率分別是84.9％(45/53)、86.3％(44/51)，差異無統(tǒng)計(jì)學(xué)意義(P=1.00)。 2．經(jīng)過10天的治療后發(fā)現(xiàn)標(biāo)準(zhǔn)劑量組的不良反應(yīng)發(fā)生率明顯高于小劑量組，A組62.3%，B組18.2%(P0.05)。 3． A組(標(biāo)準(zhǔn)劑量組)；B組(小劑量組)治療10天后的費(fèi)用分別為(327.6元、258.6元)。 結(jié)論： 1.小劑量的抗生素聯(lián)合抑酸藥方案與標(biāo)準(zhǔn)劑量的抗生素相比，根除幽門螺桿菌是有效的，但兩種治療方案與公認(rèn)的標(biāo)準(zhǔn)根治率相比均不理想。 2．小劑量抗生素聯(lián)合抑酸藥與標(biāo)準(zhǔn)劑量聯(lián)合抑酸藥方案相比，不良反應(yīng)發(fā)生率及依從性更好； 3．小劑量組與標(biāo)準(zhǔn)劑量組相比成本較低。
[Abstract]:Objective: to treat Helicobacter pylori by clinical observation of 10 days standard antibiotics combined with acid suppressants and small doses of antibiotics combined with acid suppressants. To assess the effects of standard doses and low doses of antibiotics combined with acid suppressants on the cure rate, adverse reactions, compliance, and cost of Helicobacter pylori. Methods: one hundred and eight patients with Helicobacter pylori infection from June 2011 to June 2012 in our hospital were randomly divided into two groups: group A (standard dose), lansoprazole 15 mg / g, amoxicillin 1 g, clarithromycin 500 mg / g, 1st, respectively. The course of treatment was 10 days in group B (small dose of lansoprazole 15 mg), twice in 1st, amoxicillin 500 mg / g, clarithromycin 250 mg / g, 1st, 3 times; The course of treatment was 10 days. Urea breath test (UBTT) was performed after at least 4 weeks of withdrawal or at least 2 weeks after discontinuation of acid suppressants. Compliance and adverse reactions and costs of the whole treatment period were evaluated. Results one hundred and eight patients with Helicobacter pylori infection (male 54, female 54; mean age 51.6 鹵12.2 years) were randomly divided into group A (standard dose group) and group B (small dose group). 1. After treatment, the eradication rates of group A and group B were 83.3 / 54 and 81.5 / 54, respectively. There was no significant difference in eradication rate between group A and group B (P = 1.00). PP analysis showed that the eradication rates of group A and B were 84.9% / 5386.34454 / 51, respectively, and there was no significant difference between two groups (P = 1.00). 2. After 10 days of treatment, it was found that the incidence of adverse reactions in the standard dose group was significantly higher than that in the low dose group (62.3B). 3. The cost of group A (standard dose group) and group B (small dose group) after 10 days treatment were 327.6 yuan / 258.6 yuan respectively. Conclusion:. 1. It is effective to eradicate Helicobacter pylori compared with the standard dose of antibiotics in combination with low dose antibiotics, but the two treatments are not ideal compared with the accepted standard cure rate. 2. The incidence of adverse reactions and compliance of low dose antibiotics combined with acid suppressants were better than those of standard dosage combination. 3. The cost of low dose group was lower than that of standard dose group.
【學(xué)位授予單位】：石河子大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R516

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