發(fā)布時間：2018-01-22 13:47

  本文關(guān)鍵詞： 慢性乙型肝炎 Th細(xì)胞 病情評估　出處：《中國現(xiàn)代醫(yī)學(xué)雜志》2017年03期 　論文類型：期刊論文

【摘要】：目的分析外周血中輔助性T細(xì)胞17(Th17)表面CC趨化因子受體4(CCR4)、CC趨化因子受體6(CCR6)、CXC亞族趨化因子受體3(CXCR3)表達(dá)量檢測對慢性乙型肝炎患者病情評估的價值。方法選取2013年8月-2015年12月在該院接受治療的乙型肝炎患者118例作為觀察組,同期在該院接受健康體檢的肝功能正常人群142例作為對照組,對比兩組外周血Th17細(xì)胞表面CCR4、CCR6、CXCR3表達(dá)水平,血清纖維化指標(biāo)及肝功能指標(biāo),并進(jìn)一步分析CCR4、CCR6、CXCR3表達(dá)量與慢性乙肝患者病情嚴(yán)重程度的相關(guān)性。結(jié)果慢性乙肝患者的外周血Th17細(xì)胞表面CCR4、CCR6、CXCR3表達(dá)水平,透明質(zhì)酸(HA)、層黏連蛋白(LN)、Ⅳ型膠原(Ⅳc)、Ⅲ型前膠原(PCⅢ)值,丙氨酸轉(zhuǎn)移酶(ALT)、白蛋白(Alb)、總膽紅素(TBIL)值均高于對照組,球蛋白(Glo)值低于對照組,隨著慢性乙肝病情加重,外周血Th17細(xì)胞表面CCR4、CCR6、CXCR3表達(dá)水平,HA、LN、Ⅳc、PCⅢ值,ALT、Alb、TBIL值進(jìn)一步上升,Glo值下降。CCR4、CCR6、CXCR3表達(dá)量與慢性乙肝患者的外周血HA、LN、Ⅳc、PCⅢ、ALT、Alb、TBIL呈正相關(guān),與Glo呈負(fù)相關(guān)(P0.05)。結(jié)論慢性乙肝患者存在外周血Th17細(xì)胞表面CCR4、CCR6、CXCR3異常表達(dá),其與患者病情嚴(yán)重程度直接相關(guān),可以作為乙肝治療的新靶點(diǎn)。
[Abstract]:Objective to analyze CC chemokine receptor (CCR4) and CC chemokine receptor (CCR6) on the surface of peripheral blood helper T cell 17 (Th17). CXC subfamily chemokine receptor 3 (CXCR3). Methods 118 patients with chronic hepatitis B who were treated in our hospital from August 2013 to December 2015 were selected as the observation group. At the same time, 142 healthy persons with normal liver function were taken as the control group. The expression level of CCR4 and CCR6 CXCR3 on the surface of peripheral blood Th17 cells was compared between the two groups. Serum fibrosis index and liver function index, and CCR4 and CCR6 were further analyzed. Results the expression of CCR4 and CCR6CXCR3 on the surface of peripheral blood Th17 cells in patients with chronic hepatitis B was correlated with the severity of chronic hepatitis B. Hyaluronic acid (HA), laminin (LN), type 鈪，

本文編號：1454834