慢性疼痛（chronic pain,CP）通常是指在傷病愈合后仍持續(xù)并超過三個(gè)月的疼痛。其發(fā)生率較高,給患者個(gè)人及其家庭造成重大的身心和經(jīng)濟(jì)負(fù)擔(dān),并對社會(huì)健康系統(tǒng)產(chǎn)生消極影響。研究者已經(jīng)對慢性疼痛的發(fā)生和維持機(jī)制進(jìn)行了廣泛關(guān)注。其中,恐懼回避模型（fear-avoidance model）強(qiáng)調(diào)了疼痛恐懼（fear of pain,FOP）在慢性疼痛的發(fā)生和維持過程中起著重要作用。疼痛恐懼是指對疼痛進(jìn)行負(fù)面解釋,即把疼痛等同于傷害,認(rèn)為疼痛是災(zāi)難性的,導(dǎo)致在預(yù)期疼痛或體驗(yàn)疼痛時(shí)產(chǎn)生過度緊張、恐懼的情緒反應(yīng)。疼痛恐懼可以通過直接經(jīng)驗(yàn)、言語威脅信息和觀察學(xué)習(xí)等途徑獲得,并且可以泛化到與原始恐懼相關(guān)的刺激或情境類似的新的刺激或情境中。目前已經(jīng)有許多研究,采用行為指標(biāo)（例如反應(yīng)時(shí)和眼球運(yùn)動(dòng)）,在健康和臨床樣本中證明了較高的恐懼-回避相關(guān)信念和面對傷害性刺激時(shí)較差的功能反應(yīng)存在很高的相關(guān)。但是,對疼痛恐懼潛在的認(rèn)知神經(jīng)基礎(chǔ)的研究還相對較少,結(jié)果也存在不一致。此外,從動(dòng)機(jī)的角度來看沖突情境中或者延遲情境下高疼痛恐懼個(gè)體的回避行為,可能會(huì)對恐懼回避模型有進(jìn)一步的認(rèn)識(shí)。研究1和研究2通過測量健康個(gè)體暴露... 

【文章來源】：西南大學(xué)重慶市 211工程院校 教育部直屬院校

【文章頁數(shù)】：188 頁

【學(xué)位級(jí)別】：博士

【文章目錄】：
摘要
ABSTRACT
1 LITERATURE REVIEW
    1.1 PAIN AND CHRONIC PAIN
    1.2 FEAR OF PAIN
    1.3 THE THEORY RELATED TO FOP
    1.4 FORMULATION OF HYPOTHESIS
    1.5 IMPORTANCE AND INNOVATIONS
2 STUDY1 FEAR OF PAIN AND EVENT-RELATED POTENTIALS DURING EXPOSURE TO IMAGE-CUED SENSORY STIMULATION
    2.1 INTRODUCTION
    2.2 MATERIAL AND METHODS
    2.3 RESULTS
    2.4 DISCUSSION
    2.5 CONCLUSIONS
3 STUDY2 EFFECTS OF TRAIT FEAR OF PAIN ON EVENT-RELATED POTENTIALS TO WORD CUES THAT SIGNAL POTENTIAL PAIN
    3.1 INTRODUCTION
    3.2 MATERIAL AND METHODS
    3.3 RESULTS
    3.4 DISCUSSION
    3.5 CONCLUSIONS
4 STUDY3 EFFECTS OF TRAIT FEAR OF PAIN ON NEURAL RESPONSES TO CUED POTENTIAL PAIN IN CHRONIC PAIN:AN FMRI STUDY
    4.1 INTRODUCTION
    4.2 METHOD AND MATERIALS
    4.3 RESULTS
    4.4 DISCUSSION
    4.5 CONCLUSION
5 STUDY4 ASSOCIATIONS OF GRAY MATTER VOLUME TO THE PRESENCE OF CHRONIC PAIN:A PRELIMINARY VOXEL-BASED MORPHOMETRY STUDY
    5.1 INTRODUCTION
    5.2 MATERIAL AND METHODS
    5.3 RESULTS
    5.4 DISCUSSION
    5.5 CONCLUSION
6 STUDY5 ALTERATIONS OF AMYGDALA RESTING-STATE FUNCTIONAL CONNECTIVITY IN YOUNG ADULTS WITH CHRONIC PAIN
    6.1 INTRODUCTION
    6.2 MATERIAL AND METHODS
    6.3 RESULTS
    6.4 DISCUSSION
    6.5 CONCLUSIONS
7 STUDY6 TRAIT FEAR OF PAIN AS AN IMPACT ON DECISION MAKING IN CONFLICT SITUATIONS
    7.1 INTRODUCTION
    7.2 MATERIAL AND METHODS
    7.3 RESULTS
    7.4 DISCUSSION
    7.5 CONCLUSIONS
8 STUDY7 THE IMPACT OF DENTAL PAIN FEAR ON TEMPORAL PREFERENCE:DISCOUNTING OF DELAYED PAIN-RELATED AND MONETARY OUTCOMES
    8.1 INTRODUCTION
    8.2 MATERIALS AND METHODS
    8.3 RESULTS
    8.4 DISCUSSION
    8.5 CONCLUSION
9 GENERAL DISCUSSION
10 CONCLUSIONS
REFERENCES
APPENDIX
ACKNOWLEDGEMENTS
ARTICLES PUBLISHED



本文編號(hào)：3496531