中國(guó)和巴基斯坦帕金病的研究及其差異
發(fā)布時(shí)間：2019-05-16 00:42
【摘要】：目的：原發(fā)性帕金森病在世界各地都有發(fā)生。本病普遍存在于各個(gè)國(guó)家各個(gè)社會(huì)階層,帕金森病的發(fā)病率和患病率隨著年齡的增加而增加,目前在65歲以上人群里發(fā)病率為1%。預(yù)計(jì)到2040年,帕金森病以及其他神經(jīng)變性病(如阿爾茲海默病和運(yùn)動(dòng)神經(jīng)元病等)將超過癌癥成為第二大常見死亡原因,而且到2040年帕金森病的發(fā)病率將增加4倍。在美國(guó)將近有100萬人患有帕金森病,而且每年約有65000人被新診斷為帕金森病。全世界每年用于帕金森病治療的費(fèi)用大約需要270億元。在歐洲和美國(guó)都有一些關(guān)于帕金森病花費(fèi)的研究,但是這種研究在巴基斯坦還較少見。帕金森病病程進(jìn)行性加重,其發(fā)病率逐漸增加,這給社會(huì)、健康保健提供者、患者自己以及家庭帶來了巨大的經(jīng)濟(jì)負(fù)擔(dān)。張和羅馬綜述了世界各地帕金森病的發(fā)病情況,報(bào)道說中國(guó)、日本和非洲的帕金森病患病率明顯低于西方國(guó)家。根據(jù)對(duì)巴基斯坦三個(gè)不同地區(qū)逐家逐戶的調(diào)查,巴基斯坦的帕金森病患病率較低。巴基斯坦沒有統(tǒng)一的,大規(guī)模的,全國(guó)性的有關(guān)帕金森病的發(fā)病率和患病率的流行病學(xué)數(shù)據(jù)。對(duì)帕金森患者的治療和管理的主要目的是延長(zhǎng)壽命和限制運(yùn)動(dòng)障礙的進(jìn)展。現(xiàn)在健康護(hù)理專業(yè)人員確信,醫(yī)療保健的目標(biāo)是不僅是照顧病人和提高生存率,而且也要提高他們的生活質(zhì)量。生活質(zhì)量越來越被認(rèn)為健康護(hù)理的重要方面,因?yàn)樗w現(xiàn)了患者自身角度對(duì)他們健康的看法。像帕金森這樣的慢性疾病的病人的生活質(zhì)量包括他們的癥狀和身體機(jī)能也包括心理變化,我研究了中國(guó)和巴基斯坦這兩個(gè)種族的帕金森病患者,對(duì)他們的臨床特征,發(fā)病年齡,治療方法,治療花費(fèi)和生活質(zhì)量進(jìn)行了評(píng)估和比較。 方法：對(duì)病人的研究和報(bào)告來自中國(guó)和巴基斯坦兩個(gè)國(guó)家。帕金森患者分別來自中國(guó)山東省濟(jì)南市齊魯醫(yī)院和巴基斯坦的拉合爾醫(yī)院。在門診對(duì)患者的臨床特征,實(shí)驗(yàn)室檢查和其他調(diào)查進(jìn)行記錄和分析。然后從兩個(gè)醫(yī)院分別選取50例患者。記錄下完整的處方信息和治療的花費(fèi)。我們一共調(diào)查了100名患者。來自中國(guó)和巴基斯坦各50例患者,其中巴基斯男性42例,女性8例,中國(guó)男性44例,女性6例。巴基斯坦患者的平均年齡為56歲,中國(guó)的為51.18歲。 結(jié)果：我們發(fā)現(xiàn)與中國(guó)一樣,86%的巴基斯坦患者在50或60歲左右發(fā)病�；颊邅砭驮\時(shí)疾病的平均病程在中國(guó)為6.9年在巴基斯坦為7.15年。治療的花費(fèi)在中國(guó)為53.51美元而巴基斯坦為26.79美元。強(qiáng)直,運(yùn)動(dòng)遲緩,震顫,缺乏表情,原始反射,難以進(jìn)行精細(xì)的工作和行走困難是巴基斯坦和中國(guó)患者是最常見的臨床癥狀。在中國(guó),大部分患者在I或II期(Hoehn-Yahr分級(jí))疾病階段初診,而在巴基斯坦,患者第一次來看病的階段大多在疾病2.0-2.5期。在中國(guó)患者以單側(cè)癥狀為主,這在巴基斯坦是比較少見的。 結(jié)論：：震顫,僵直,行走困難,運(yùn)動(dòng)遲緩,難以進(jìn)行精細(xì)的做工是帕金森病最常見的臨床特征。疾病的嚴(yán)重程度隨疾病的持續(xù)時(shí)就愛你而增加。雖然在巴基斯坦的成本管理比中國(guó)少,但是生活質(zhì)量比中國(guó)好。認(rèn)知功能障礙并不少見,與這些患者的疾病的病程和發(fā)病年齡相關(guān)。在中國(guó)患者的平均壽命較高是由于較高的生活質(zhì)量和與巴基斯坦相比較好的社會(huì)狀況,因?yàn)槿メt(yī)院就診的巴基斯坦患者主要是農(nóng)民,退休工人,所以病人常常不安規(guī)定服藥。在巴基斯坦中年以后容易患帕金森病,患者大多為50歲以上的人。發(fā)病的平均年齡是60歲。然而,有些巴基斯坦醫(yī)師在過去幾年的報(bào)道中注意到“早發(fā)性帕金森病’,估計(jì)5%到10%的患者在40歲以下。治療處方包括息寧(75%左旋多巴+25%芐絲肼)仍然是在巴基斯坦治療帕金森病的唯一藥物。PD的管理也要求治療相關(guān)的問題和并發(fā)癥如吞咽困難,便秘,性功能障礙,體位性低血壓等,這些癥狀容易被患者忽視。
[Abstract]:Objective: The primary Parkinson's disease has occurred in all parts of the world. The incidence and prevalence of Parkinson's disease are increased with the increase of age, and the incidence of Parkinson's disease is 1% in the population over the age of 65. It is expected that in 2040, Parkinson's disease and other neurodegenerative diseases, such as Alzheimer's disease and motor neuron disease, will be more than the second most common cause of death, and the incidence of Parkinson's disease will increase by four times in 2040. In the United States, nearly 1 million people have Parkinson's disease, and about 65,000 people are diagnosed with Parkinson's disease every year. The cost of the worldwide treatment of Parkinson's disease is about $22.7 billion a year. There are some studies on parkinson's disease in both Europe and the United States, but the study is rare in Pakistan. The progressive increase in the course of Parkinson's disease, with a gradual increase in the incidence of Parkinson's disease, has brought enormous economic burden to society, health care providers, patients themselves and the family. Zhang and Rome reviewed the incidence of Parkinson's disease in various parts of the world and reported that the prevalence of Parkinson's disease in China, Japan and Africa was significantly lower than that of Western countries. The prevalence of Parkinson's disease in Pakistan is low based on a case-by-case survey of three different parts of Pakistan. There is no uniform, large-scale, nationwide epidemiological data on the incidence and prevalence of Parkinson's disease in Pakistan. The primary objective of the treatment and management of Parkinson's is to extend the life and limit the progression of dyskinesia. Health care professionals are now convinced that the goal of health care is not only to care for patients and to improve survival, but also to improve their quality of life. The quality of life is increasingly being considered as an important aspect of health care, as it represents the patient's own view of their health. The quality of life of patients with chronic diseases like Parkinson's disease, including their symptoms and physical functions, also includes psychological changes, and I have studied patients with Parkinson's disease in both China and Pakistan, their clinical characteristics, the age of onset, and the methods of treatment, The treatment cost and quality of life were evaluated and compared. Methods: The study and report of the patient came from two countries in China and Pakistan The patients of Parkinson's disease are from the Qilu Hospital of Jinan, Shandong Province and the Lahore Medical College in Pakistan, respectively. The hospital. Record and score the clinical features, laboratory and other investigations of the patient in the clinic Analysis. Then select 50 patients from two hospitals. A. Record the complete prescription information and the cost of treatment Fee. We've been investigating a total of 100. People from 50 patients in China and Pakistan, including 42 male and 8 female,44 female,6 female The average age of patients in Pakistan is 56 years and China is 51.18. As a result, we found that, like China,86% of Pakistani patients were at 50 or 60 years of age The average course of the disease at the time of the patient's visit was 6.9 years in China and 7 in Pakistan. 15 years. The cost of treatment is $53.51 in China and 26.7 in Pakistan It is the most common presence of Pakistan and Chinese patients with rigidity, bradykinesia, tremors, lack of expression, original reflection, difficulty in fine work and walking. The symptoms of the bed. In China, most of the patients were first diagnosed at the stage I or II (Hoehn-Yahr), while in Pakistan, the first time the patient came to the hospital, most of the patients were in the disease version 2.0-2. .5. In Chinese patients with one-sided symptoms, this is the case in Pakistan It's rare. Conclusion: Tremor, rigidity, difficulty in walking, slow movement and difficulty in fine workmanship are the most common in Parkinson's disease. Clinical characteristics of the disease. The severity of the disease is dependent on the duration of the disease Love you. Although the cost management in Pakistan is less than China, the quality of life The amount is better than that of China. The cognitive impairment is not uncommon, and the course of the disease and the onset of the disease in these patients The age of the disease is related to the age of the disease. The higher life expectancy in Chinese patients is due to the higher quality of life and the social situation in comparison to that of Pakistan, because the Pakistani patients who go to the hospital are mainly farmers and retired workers, so the patient often does not The patients with Parkinson's disease are prone to parkinson's disease after middle-age in Pakistan, with a majority of 50 patients The average year of the onset of the disease. The age was 60. However, some Pakistani doctors, in the past few years, noted that "early-onset Parkinson's disease ', estimated to be between 5 and 10% of patients, The treatment prescription, including Xining (75% levodopa + 25%), is still in the treatment of Parkinson's disease in Pakistan The management of PD also requires treatment-related problems and complications such as dysphagia, constipation, sexual dysfunction, orthostatic hypotension, etc.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R742.5
本文編號(hào)：2477888
[Abstract]:Objective: The primary Parkinson's disease has occurred in all parts of the world. The incidence and prevalence of Parkinson's disease are increased with the increase of age, and the incidence of Parkinson's disease is 1% in the population over the age of 65. It is expected that in 2040, Parkinson's disease and other neurodegenerative diseases, such as Alzheimer's disease and motor neuron disease, will be more than the second most common cause of death, and the incidence of Parkinson's disease will increase by four times in 2040. In the United States, nearly 1 million people have Parkinson's disease, and about 65,000 people are diagnosed with Parkinson's disease every year. The cost of the worldwide treatment of Parkinson's disease is about $22.7 billion a year. There are some studies on parkinson's disease in both Europe and the United States, but the study is rare in Pakistan. The progressive increase in the course of Parkinson's disease, with a gradual increase in the incidence of Parkinson's disease, has brought enormous economic burden to society, health care providers, patients themselves and the family. Zhang and Rome reviewed the incidence of Parkinson's disease in various parts of the world and reported that the prevalence of Parkinson's disease in China, Japan and Africa was significantly lower than that of Western countries. The prevalence of Parkinson's disease in Pakistan is low based on a case-by-case survey of three different parts of Pakistan. There is no uniform, large-scale, nationwide epidemiological data on the incidence and prevalence of Parkinson's disease in Pakistan. The primary objective of the treatment and management of Parkinson's is to extend the life and limit the progression of dyskinesia. Health care professionals are now convinced that the goal of health care is not only to care for patients and to improve survival, but also to improve their quality of life. The quality of life is increasingly being considered as an important aspect of health care, as it represents the patient's own view of their health. The quality of life of patients with chronic diseases like Parkinson's disease, including their symptoms and physical functions, also includes psychological changes, and I have studied patients with Parkinson's disease in both China and Pakistan, their clinical characteristics, the age of onset, and the methods of treatment, The treatment cost and quality of life were evaluated and compared. Methods: The study and report of the patient came from two countries in China and Pakistan The patients of Parkinson's disease are from the Qilu Hospital of Jinan, Shandong Province and the Lahore Medical College in Pakistan, respectively. The hospital. Record and score the clinical features, laboratory and other investigations of the patient in the clinic Analysis. Then select 50 patients from two hospitals. A. Record the complete prescription information and the cost of treatment Fee. We've been investigating a total of 100. People from 50 patients in China and Pakistan, including 42 male and 8 female,44 female,6 female The average age of patients in Pakistan is 56 years and China is 51.18. As a result, we found that, like China,86% of Pakistani patients were at 50 or 60 years of age The average course of the disease at the time of the patient's visit was 6.9 years in China and 7 in Pakistan. 15 years. The cost of treatment is $53.51 in China and 26.7 in Pakistan It is the most common presence of Pakistan and Chinese patients with rigidity, bradykinesia, tremors, lack of expression, original reflection, difficulty in fine work and walking. The symptoms of the bed. In China, most of the patients were first diagnosed at the stage I or II (Hoehn-Yahr), while in Pakistan, the first time the patient came to the hospital, most of the patients were in the disease version 2.0-2. .5. In Chinese patients with one-sided symptoms, this is the case in Pakistan It's rare. Conclusion: Tremor, rigidity, difficulty in walking, slow movement and difficulty in fine workmanship are the most common in Parkinson's disease. Clinical characteristics of the disease. The severity of the disease is dependent on the duration of the disease Love you. Although the cost management in Pakistan is less than China, the quality of life The amount is better than that of China. The cognitive impairment is not uncommon, and the course of the disease and the onset of the disease in these patients The age of the disease is related to the age of the disease. The higher life expectancy in Chinese patients is due to the higher quality of life and the social situation in comparison to that of Pakistan, because the Pakistani patients who go to the hospital are mainly farmers and retired workers, so the patient often does not The patients with Parkinson's disease are prone to parkinson's disease after middle-age in Pakistan, with a majority of 50 patients The average year of the onset of the disease. The age was 60. However, some Pakistani doctors, in the past few years, noted that "early-onset Parkinson's disease ', estimated to be between 5 and 10% of patients, The treatment prescription, including Xining (75% levodopa + 25%), is still in the treatment of Parkinson's disease in Pakistan The management of PD also requires treatment-related problems and complications such as dysphagia, constipation, sexual dysfunction, orthostatic hypotension, etc.
【學(xué)位授予單位】：山東大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2013
【分類號(hào)】：R742.5
【共引文獻(xiàn)】
相關(guān)期刊論文 前2條
1 王順;戚秀杰;韓迪;;頭部電針透穴療法對(duì)帕金森病模型大鼠黑質(zhì)TH及DAT基因表達(dá)的影響[J];中國(guó)針灸;2009年05期
2 戚秀杰;王順;;頭部電針透穴對(duì)帕金森病模型大鼠黑質(zhì)神經(jīng)生長(zhǎng)因子表達(dá)的影響[J];中國(guó)針灸;2011年05期
相關(guān)博士學(xué)位論文 前3條
1 高慧明;腦內(nèi)炎癥介導(dǎo)的帕金森�。翰∫蚝桶l(fā)病機(jī)制研究[D];大連醫(yī)科大學(xué);2003年
2 徐t2t2;人參皂苷-Re對(duì)帕金森病模型小鼠腦內(nèi)多巴胺能神經(jīng)元保護(hù)作用機(jī)制的研究[D];沈陽藥科大學(xué);2004年
3 戚秀杰;頭部電針透穴療法對(duì)帕金森病大鼠黑質(zhì)多巴胺能神經(jīng)元保護(hù)作用研究[D];黑龍江中醫(yī)藥大學(xué);2008年
相關(guān)碩士學(xué)位論文 前2條
1 李偉平;構(gòu)建重組大腸桿菌生物合成左旋多巴[D];江南大學(xué);2005年
2 程宇核;電針對(duì)帕金森病模型大鼠黑質(zhì)小膠質(zhì)細(xì)胞及促炎性細(xì)胞因子的影響[D];湖北中醫(yī)藥大學(xué);2010年
，本文編號(hào)：2477888
本文鏈接：http://sikaile.net/guanlilunwen/chengbenguanlilunwen/2477888.html
最近更新
教材專著
