在真核細(xì)胞內(nèi)主要存在兩種蛋白降解系統(tǒng),自噬—溶酶體系統(tǒng)和泛素—蛋白酶體系統(tǒng)(UPS),對(duì)維持蛋白穩(wěn)態(tài)至關(guān)重要。本文綜述了自噬—溶酶體系統(tǒng)和UPS的組成、功能、相互作用、功能相關(guān)性以及與腫瘤的關(guān)系,其作為藥物靶標(biāo)的可行性,對(duì)于未來(lái)腫瘤靶向藥物的研制具有重要的指導(dǎo)作用,同時(shí)對(duì)于全面理解自噬—溶酶體系統(tǒng)和UPS的功能和機(jī)制也有重要的參考價(jià)值。

【文章頁(yè)數(shù)】：17 頁(yè)

【文章目錄】：
1 Introduction
2 Introduction to eukaryotic protein deg-radation system
3 Ubiquitin as the core of UPS and au-tophagy
4 Ubiquitin-based proteasome
5 Ubiquitin-based autophagy degradation
6 Antagonism and interaction between 6UPS and autophagy
    6.1 Interference from UPS to autophagy
    6.2 Interference from autophagy to UPS
    6.3 Interplay between autophagy and UPS
    6.4 UPS and autophagy interaction
    6.5 Interaction between autophagy and UPS through the domain
7 Autophagy and cancer
8 UPS and cancer
9 DUB and cancer
1 0 DUB and autophagy simultaneous positioning
1 1 Human diseases and drug targeted therapy
1 2 Conclusions and prospects



本文編號(hào)：3993672