本文選題：肺癌 + 能譜CT成像　； 參考：《重慶醫(yī)科大學(xué)》2017年碩士論文

【摘要】：目的采用能譜CT技術(shù)對肺癌癌周灌注進(jìn)行定量研究,探討其灌注變化情況及不同分類情況下的灌注差異。方法經(jīng)病理證實的81例肺癌患者均行能譜CT平掃和增強(qiáng)掃描。在動脈期碘基物質(zhì)圖上分別測量癌周肺組織及健側(cè)鏡像區(qū)肺組織碘基值,然后計算平均碘濃度(average iodine concentration,ICa),分析比較:所有病例組、中央型及周圍型肺癌組癌周與健側(cè)鏡像區(qū)肺組織的ICa差異;不同部位(中央型、周圍型)、腫瘤大小(A組d≤3 cm、B組3d≤7 cm)、病理類型(鱗癌、腺癌、小細(xì)胞肺癌)及分化程度(低、低-中、中分化)肺癌組癌周ICa組內(nèi)差異。結(jié)果(1)81例肺癌[(1.26±0.42)mg/ml]、32例中央型[(1.12±0.33)mg/ml]及49例周圍型[(1.35±0.45)mg/ml]肺癌癌周肺組織ICa明顯低于相應(yīng)健側(cè)鏡像區(qū)[(1.65±0.61)mg/ml,(1.63±0.69)mg/ml及(1.66±0.56)mg/ml],差異均具有統(tǒng)計學(xué)意義(P0.01)。(2)中央型肺癌癌周肺組織ICa[(1.12±0.33)mg/ml]明顯低于周圍型[(1.35±0.45)mg/ml](P0.01),10例小細(xì)胞肺癌癌周肺組織ICa[(0.94±0.20)mg/ml]低于37例鱗癌[(1.23±0.40)mg/ml]及34例腺癌[(1.37±0.45)mg/ml](P0.05),而后兩者之間差異無統(tǒng)計學(xué)意義(P0.05)。(3)不同大小肺癌之間以及不同分化程度肺癌之間癌周肺組織ICa差異均無統(tǒng)計學(xué)意義(P0.05)。結(jié)論肺癌癌周灌注普遍減低,且中央型肺癌低于周圍型肺癌,小細(xì)胞肺癌低于非小細(xì)胞肺癌。肺癌癌周能譜CT灌注特征具有一定理論和臨床價值。
[Abstract]:Objective to quantitatively study the pericancerous perfusion of lung cancer by energy dispersive CT (EDS), and to explore the changes of perfusion and the difference of perfusion under different classification. Methods 81 patients with lung cancer proved pathologically underwent plain scan and enhanced scan. The iodine base values of lung tissue around carcinoma and normal mirror region were measured on the arterial phase iodized substance map, and the mean iodine concentration (average iodine concentration) was calculated. The difference of IC a between peripheral and peripheral lung cancer, the size of tumor in different parts (central type, peripheral type), the size of tumor (group A d 鈮，

本文編號：2096217