脾腫大是門脈高壓癥的重要并發(fā)癥之一[1]。據(jù)統(tǒng)計(jì)，大約36%-92%的肝硬化患者存在著不同程度脾臟腫大[2]，特別是在我國(guó)，乙型病毒性肝炎導(dǎo)致的失代償期肝硬化是引起脾腫大的主要原因之一[3]，嚴(yán)重危害著患者的生命健康。門脈高壓性脾臟腫大可以產(chǎn)生一系列的并發(fā)癥[4-5]：1、壓迫腹腔周圍臟器產(chǎn)生相應(yīng)癥狀；2、脾功能亢進(jìn)導(dǎo)致貧血；3、導(dǎo)致機(jī)體免疫功能下降；4、可能因輕微碰撞而發(fā)生破裂出血；5、機(jī)體儲(chǔ)血能力下降等。纖維組織增生是門脈高壓癥脾臟腫大的重要原因之一，也是其主要病理特征之一。JAK2/STAT3信號(hào)轉(zhuǎn)導(dǎo)通路是一條多種細(xì)胞因子參與的信號(hào)轉(zhuǎn)導(dǎo)途徑，最初因?yàn)閰⑴c細(xì)胞增殖而被發(fā)現(xiàn)，在后續(xù)的研究中發(fā)現(xiàn)該信號(hào)轉(zhuǎn)導(dǎo)通路與機(jī)體的多種組織器官的細(xì)胞分化、凋亡、免疫功能改變等密切相關(guān)[6]。有研究表明該信號(hào)轉(zhuǎn)導(dǎo)通路可能參與機(jī)體組織器官的纖維化過(guò)程[7-12]。在腎間質(zhì)纖維化過(guò)程中JAK2/STAT3信號(hào)轉(zhuǎn)導(dǎo)通路被激活提示該通路可能參與了組織纖維化。JAK2/STAT3信號(hào)轉(zhuǎn)導(dǎo)通路還通過(guò)調(diào)節(jié)多種細(xì)胞因子促進(jìn)血管平滑肌細(xì)胞和成纖維細(xì)胞增生、遷移。既往研究表明JAK2/STAT3信號(hào)轉(zhuǎn)導(dǎo)通路在組織纖維化過(guò)程... 

【文章來(lái)源】：中國(guó)人民解放軍空軍軍醫(yī)大學(xué)陜西省211工程院校

【文章頁(yè)數(shù)】：47 頁(yè)

【學(xué)位級(jí)別】：碩士

【部分圖文】：

JAK2蛋白晶體結(jié)構(gòu)示意圖

JAK2/STAT3信號(hào)傳導(dǎo)通路激活與調(diào)控示意圖

Masson三色染色結(jié)果（×200）

【參考文獻(xiàn)】：
期刊論文
[1]Daily genetic profiling indicates JAK/STAT signaling promotes early hepatic stellate cell transdifferentiation[J]. Ashley M Lakner,Cathy C Moore,Alyssa A Gulledge,Laura W Schrum.  World Journal of Gastroenterology. 2010(40)
[2]Stability of a rat model of prehepatic portal hypertension caused by partial ligation of the portal vein[J]. Zhe Wen, Hui-Min Xia, Department of Surgery, Guangzhou Children’s Hospital Affi liated to Guangzhou Medical College, Guangzhou 510120, Guangdong Province, China Jin-Zhe Zhang, Ya-Jun Chen, Department of Surgery, Beijing Children’s Hospital Affiliated to Capital Medical University, Beijing 100045, China Chun-Xiao Yang, Department of Surgery, Linzi People’s Hospital, Zibo 255400, Shandong Province, China.  World Journal of Gastroenterology. 2009(32)
[3]Clinical characteristics of idiopathic portal hypertension[J]. Ozgur Harmanci,Yusuf Bayraktar.  World Journal of Gastroenterology. 2007(13)
[4]Expression of TNF-α and VEGF in the esophagus of portal hypertensive rats[J]. Zhao-Hui Yin, Xun-Yang Liu, Rang-Lang Huang, Shu-Ping Ren, Department of General Surgery, Third Xiangya Hospital, Central South University, Changsha 410013, Hunan Province, China.  World Journal of Gastroenterology. 2005(08)
[5]Immunohistochemical　Analysis　of　Growth　Factor　Expression　and　Localization　in　Gastric　Coronary　Vein　of　Cirrhotic　Patients[J]. YANG Zhen; TIAN Lei; PENG Lin; QIU Fazu(Department of Surgery, Tongji Hospital, Tongji Medical University Wuhan 430030).  同濟(jì)醫(yī)科大學(xué)學(xué)報(bào)(外文版). 1996(04)
[6]門靜脈高壓癥巨脾原位保留與異位移植組織變化與功能的比較[J]. 汪謙,程慶君,郭金鵬.  蚌埠醫(yī)學(xué)院學(xué)報(bào). 1991(01)



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