缺血性腦卒中和短暫性腦缺血發(fā)作患者血清miR-23b-3p水平變化的比較研究
發(fā)布時(shí)間:2021-11-23 19:45
目的探討短暫性腦缺血發(fā)作(transient ischemic attack, TIA)患者和缺血性腦卒中(ischemic stroke, IS)患者血清miR-23b-3p的水平變化。方法選取常州市第一人民醫(yī)院神經(jīng)內(nèi)科2017年8月~2019年4月收治的156例IS患者,71例TIA患者和85例常規(guī)體檢的健康對照者納入研究。采用實(shí)時(shí)熒光定量PCR(quantitative reverse-transcription PCR, qRT-PCR)技術(shù)檢測受試者血清miR-23b-3p水平并分析相關(guān)生化指標(biāo)。結(jié)果與健康對照組相比,IS組(t=4.517,P<0.001)及TIA患者組(t=2.728, P<0.001)血清miR-23b-3p水平均顯著升高,且IS組高于TIA患者組(t=3.364,P=0.043)。此外,重度IS組miR-23b-3p水平明顯高于中度IS(t=1.212,P=0.034)和輕度IS組(t=4.931, P<0.001),差異均有統(tǒng)計(jì)學(xué)意義。相關(guān)性分析顯示IS患者血清miR-23b-3p水平與美國國立衛(wèi)生研究院卒中量表(National ...
【文章來源】:現(xiàn)代檢驗(yàn)醫(yī)學(xué)雜志. 2020,35(05)
【文章頁數(shù)】:5 頁
【部分圖文】:
IS患者和TIA患者血清mi R-23b-3p水平
【參考文獻(xiàn)】:
期刊論文
[1]Stroke gets in your eyes: stroke-induced retinal ischemia and the potential of stem cell therapy[J]. Chase Kingsbury,Matt Heyck,Brooke Bonsack,Jea-Young Lee,Cesar V.Borlongan. Neural Regeneration Research. 2020(06)
[2]MicroRNAs in blood and cerebrospinal fluid as diagnostic biomarkers of multiple sclerosis and to monitor disease progression[J]. Bridget Martinez,Philip V Peplow. Neural Regeneration Research. 2020(04)
[3]循環(huán)微小RNA在靜脈血栓栓塞癥中的研究進(jìn)展[J]. 常運(yùn)鶴,王慶賢. 中華實(shí)驗(yàn)外科雜志. 2019 (02)
[4]頸動(dòng)脈粥樣硬化斑塊性質(zhì)與患者血清miRNA-126,miRNA-155水平的相關(guān)性研究[J]. 姜彥峰,李小俠,陳安志. 現(xiàn)代檢驗(yàn)醫(yī)學(xué)雜志. 2017(06)
本文編號(hào):3514533
【文章來源】:現(xiàn)代檢驗(yàn)醫(yī)學(xué)雜志. 2020,35(05)
【文章頁數(shù)】:5 頁
【部分圖文】:
IS患者和TIA患者血清mi R-23b-3p水平
【參考文獻(xiàn)】:
期刊論文
[1]Stroke gets in your eyes: stroke-induced retinal ischemia and the potential of stem cell therapy[J]. Chase Kingsbury,Matt Heyck,Brooke Bonsack,Jea-Young Lee,Cesar V.Borlongan. Neural Regeneration Research. 2020(06)
[2]MicroRNAs in blood and cerebrospinal fluid as diagnostic biomarkers of multiple sclerosis and to monitor disease progression[J]. Bridget Martinez,Philip V Peplow. Neural Regeneration Research. 2020(04)
[3]循環(huán)微小RNA在靜脈血栓栓塞癥中的研究進(jìn)展[J]. 常運(yùn)鶴,王慶賢. 中華實(shí)驗(yàn)外科雜志. 2019 (02)
[4]頸動(dòng)脈粥樣硬化斑塊性質(zhì)與患者血清miRNA-126,miRNA-155水平的相關(guān)性研究[J]. 姜彥峰,李小俠,陳安志. 現(xiàn)代檢驗(yàn)醫(yī)學(xué)雜志. 2017(06)
本文編號(hào):3514533
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