Repressed expression of tumour suppressor genes with concomitant amplification of oncogenes has been a molecular signature in tumorigenesis and cancer progression. The trans-membrane receptor protein, Neogenin, closely related to DCC （deleted in colorectal cancer）, structurally and functionally, is renowned for guiding axons during migration, regulating cell differentiation in CNS and beyond and controlling cell division. Emerging data have categorized neogenin in a group of structurally dispara... 

【文章來源】：東北師范大學吉林省 211工程院校 教育部直屬院校

【文章頁數(shù)】：32 頁

【學位級別】：碩士

【文章目錄】：
Abstract
Table of contents
1 Introduction
    1.1 Cancer
    1.2 Gliomas
    1.3 Neogenin
    1.4 Neogenin-dependence receptor and cancer
    1.5 Genetic-epigenetic alterations in cancer
    1.6. Thesis aim and proposal
    1.7 Significance of study
2 Materials and Methods
    2.1 Materials
        2.1.1 Laboratory equipments
        2.1.2 Reagents
        2.1.3 Tissues and cell culture
        2.1.4 Media and supplements
        2.1.5 Antibodies
        2.1.6 Buffers
    2.2 Methods
        2.2.1 Cells
        2.2.2 Tissues
        2.2.3 Storage of cells
        2.2.4 Biochemical analyses
3. Results
    3.1 Down-regulation of neogenin in gliomas compared with surrounding area and non-tumour brain tissue
    3.2 Inverse correlation between neogenin and glioma malignancy
    3.3 Loss of neogenin expression accompanies glioma recurrence
    3.4 Hypermethylation of neogenin promoter
    3.5 Induction of apoptosis in SHG 44 glioma cell line after over-expression of neogenin
4. Discussion and conclusion
    4.1 Discussion
    4.2 Summary
References
ABBREVIATIONS
Acknowledgements


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期刊論文
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