核因子E2相關(guān)因子2（nuclear facter erythroid 2-related facter 2, Nrf2）是細(xì)胞中抗氧化轉(zhuǎn)錄因子,在機(jī)體內(nèi)起到重要的抗氧化作用。研究表明,Nrf2可以通過(guò)抑制氧化應(yīng)激,降低神經(jīng)炎癥及改善線粒體功能等作用,緩解神經(jīng)退行性疾病。本文就Nrf2的結(jié)構(gòu)及其在神經(jīng)退行性疾病中的作用進(jìn)行綜述,以期為神經(jīng)退行性疾病的防治策略提供新思路。 

【文章來(lái)源】：生命的化學(xué). 2020,40(11)

【文章頁(yè)數(shù)】：8 頁(yè)

【部分圖文】：

Nrf2的結(jié)構(gòu)示意圖[3]

【參考文獻(xiàn)】：
期刊論文
[1]Keap1-Nrf2-ARE信號(hào)通路及其激活劑的研究進(jìn)展[J]. 姚娟,吳平安,李蕓,李越峰,劉東玲,劉雪楓.  中國(guó)藥理學(xué)通報(bào). 2019(10)
[2]Effect of p62 on tau hyperphosphorylation in a rat model of Alzheimer’s disease[J]. Xianhong Zheng1,Weiwei Wang2,Ruizhi Liu1,Honglan Huang3,Rihui Zhang4,Liankun Sun2 1Department of Cytobiology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,Jilin Province,China 2Department of Pathophysiology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,Jilin Province,China 3Department of Pathogen Biology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,Jilin Province,China 4Department of Physiology,Norman Bethune College of Medicine,Jilin University,Changchun 130021,Jilin Province,China.  Neural Regeneration Research. 2012(17)



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