【摘要】：目的探討雙聯(lián)抗血小板時(shí)間對(duì)癥狀性頸動(dòng)脈狹窄患者缺血性卒中復(fù)發(fā)和動(dòng)脈斑塊活動(dòng)性的影響。方法癥狀性頸動(dòng)脈狹窄患者95例,根據(jù)發(fā)病后雙聯(lián)抗血小板的持續(xù)時(shí)間,分為短期雙聯(lián)抗血小板(SD)組(療程1月)67例及延長(zhǎng)雙聯(lián)抗血小板(PD)組(療程3月)28例,2組患者的臨床資料、MES、血清MMP-7和hs-CRP水平等基線數(shù)據(jù)的差別無(wú)統(tǒng)計(jì)學(xué)意義。分析并比較2組患者經(jīng)雙聯(lián)抗血小板治療后,腦卒中復(fù)發(fā)、出血并發(fā)癥、經(jīng)顱多普勒超聲檢測(cè)微栓子(MES)、血清基質(zhì)金屬蛋白酶-7(MMP-7)和超敏C反應(yīng)蛋白(hs-CRP)水平的差別。結(jié)果 (1)隨訪6月后,SD組的MES陽(yáng)性率及血清MMP-7、hs-CRP水平分別為(38.8%,26/67),(17.35±0.95)μg/L和(13.74±1.41)mg/L,均低于入院時(shí)水平(P0.05);PD組的MES陽(yáng)性率及血清MMP-7、hs-CRP水平分別為(17.9%,5/28),(16.94±0.62)μg/L和(13.05±1.03)mg/L,均低于入院時(shí)水平(P0.05),且均低于SD組(P0.05)。(2)隨訪1年后,2組的腦梗死或短暫性腦缺血發(fā)作復(fù)發(fā)和出血并發(fā)癥的差別無(wú)統(tǒng)計(jì)學(xué)意義(P0.05)。結(jié)論 PD治療可減少癥狀性頸動(dòng)脈狹窄患者的MES,可能有利于降低缺血性卒中的復(fù)發(fā)率。
[Abstract]:Objective to investigate the effect of dual antiplatelet time on ischemic stroke recurrence and plaque activity in patients with symptomatic carotid stenosis. Methods according to the duration of double antiplatelet after onset, 95 patients with symptomatic carotid artery stenosis were divided into short-term double antiplatelet (PD) group (n = 67) and extended double antiplatelet (PD) group (n = 28). There was no significant difference in MES, serum MMP-7 and hs-CRP levels between the two groups. After double antiplatelet therapy, the recurrence of stroke and bleeding complications were analyzed and compared. The levels of serum matrix metalloprotease-7 (MMP-7) and high-sensitive C-reactive protein (hs-CRP) in microemboli (MES), were detected by transcranial Doppler ultrasound. Results (1) after 6 months follow-up, the positive rate of MES and the level of serum MMP-7,hs-CRP in SD group were (38.8%), 26 鈮，

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