【摘要】：目的探討偏頭痛患者在發(fā)作間期大腦對疼痛電刺激的反應(yīng)特點。方法收集30例發(fā)作間期的無先兆偏頭痛患者(偏頭痛組)和30名年齡、性別相匹配的健康對照者(對照組),利用腦磁圖描記術(shù)記錄正中神經(jīng)疼痛電刺激下誘導(dǎo)的腦電磁信號。比較偏頭痛組與對照組之間在痛覺處理上的差異。結(jié)果與對照組相比,偏頭痛組疼痛電刺激疼痛閾值顯著降低(P0.05),疼痛電刺激產(chǎn)生的體感誘發(fā)磁場M20潛伏期明顯延長(P0.01)。偏頭痛組疼痛誘發(fā)Gamma振蕩平均能量較對照組顯著增強(P0.01),且Gamma震蕩能量值與視覺模擬評分法(VAS)、偏頭痛殘疾程度評估量表(MIDAS)評分均呈正相關(guān)(VAS左手:r=0.45,P0.05;VAS右手:r=0.46,P0.05;MIDAS左手:r=0.47,P0.01;MIDAS右手:r=0.59,P0.01)。結(jié)論偏頭痛患者發(fā)作間期存在疼痛感覺異常,且痛覺刺激相關(guān)的皮質(zhì)興奮性增高。
[Abstract]:Objective to investigate the response of brain to pain electrical stimulation in migraine patients during interictal period. Methods 30 interictal migraine patients (migraine group) and 30 age and sex matched healthy controls (control group) were collected. The brain electromagnetic signals induced by median nerve pain were recorded by magnetography. The difference of pain management between the migraine group and the control group was compared. Results compared with the control group, the pain threshold of pain electrical stimulation in migraine group was significantly lower than that in control group (P 0.05), and the latency of somatosensory induced magnetic field M20 induced by pain electrical stimulation was significantly prolonged (P 0.01). The average energy of pain induced Gamma oscillations in migraine group was significantly higher than that in control group (P0.01), and there was a positive correlation between Gamma concussion energy and (MIDAS) score of (VAS), migraine disability assessment scale (VAS left hand: r 鈮，

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