【摘要】：目的觀察小腦頂核電刺激(FNS)對(duì)腦白質(zhì)疏松(LA)患者執(zhí)行功能的改善效果。方法將33例LA伴執(zhí)行功能障礙的患者隨機(jī)分為觀察組17例和對(duì)照組16例。兩組均給予常規(guī)藥物治療,包括針對(duì)LA給予腦蛋白水解物護(hù)腦治療,針對(duì)合并的基礎(chǔ)疾病給予對(duì)癥治療,治療20 d。觀察組在常規(guī)治療基礎(chǔ)上采用FNS治療,對(duì)患者小腦頂核進(jìn)行仿生電刺激,電流1 m A,頻率130~200 Hz,強(qiáng)度為70~100 m V,每次30 min,1次/d,連續(xù)治療20d。分別于治療前后對(duì)兩組患者進(jìn)行執(zhí)行功能評(píng)價(jià),包括Stroop色詞測(cè)試C部分(SCWT-C)、言語(yǔ)流暢性測(cè)試(VFT)、連線測(cè)試A部分和連線測(cè)試B部分(TMT-A、B)、畫鐘測(cè)驗(yàn)(CDT);進(jìn)行頭顱MRI檢查,測(cè)算執(zhí)行功能相關(guān)腦區(qū)白質(zhì)部分各向異性(FA)值。結(jié)果對(duì)照組治療前后各項(xiàng)執(zhí)行功能測(cè)試成績(jī)差異無統(tǒng)計(jì)學(xué)意義。觀察組FNS治療后SCWT-C、VFT、TMT-A及TMT-B、CDT的測(cè)試成績(jī)較治療前有所提高(P均0.05),且觀察組治療后各項(xiàng)執(zhí)行功能測(cè)試成績(jī)優(yōu)于對(duì)照組治療后(P均0.05)。對(duì)照組治療前后執(zhí)行功能相關(guān)腦區(qū)白質(zhì)FA值差異無統(tǒng)計(jì)學(xué)意義。觀察組治療后右額葉白質(zhì)、左額葉白質(zhì)、右頂葉白質(zhì)、左頂葉白質(zhì)、右扣帶束、左扣帶束的FA值均高于治療前,且高于對(duì)照組治療后(P均0.05)。結(jié)論 FNS治療可提高LA患者的執(zhí)行功能,改善執(zhí)行功能相關(guān)腦區(qū)皮層下白質(zhì)纖維微結(jié)構(gòu)的完整性。
[Abstract]:Objective to observe the effect of cerebellar fastigial nucleus stimulation (FNS) on executive function in patients with white matter osteoporosis (LA). Methods 33 patients with LA with executive dysfunction were randomly divided into observation group (n = 17) and control group (n = 16). Both groups were treated with routine drugs, including brain protein hydrolysate for LA, symptomatic treatment for basic diseases, treatment for 20 days. On the basis of routine treatment, the patients in the observation group were treated with FNS. The cerebellar fastigial nucleus was stimulated by bionic electrical stimulation. The current was 1 Ma, the frequency was 130 鈮，

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