【摘要】：目的觀察小腦頂核電刺激(FNS)對腦白質(zhì)疏松(LA)患者執(zhí)行功能的改善效果。方法將33例LA伴執(zhí)行功能障礙的患者隨機分為觀察組17例和對照組16例。兩組均給予常規(guī)藥物治療,包括針對LA給予腦蛋白水解物護腦治療,針對合并的基礎(chǔ)疾病給予對癥治療,治療20 d。觀察組在常規(guī)治療基礎(chǔ)上采用FNS治療,對患者小腦頂核進行仿生電刺激,電流1 m A,頻率130~200 Hz,強度為70~100 m V,每次30 min,1次/d,連續(xù)治療20d。分別于治療前后對兩組患者進行執(zhí)行功能評價,包括Stroop色詞測試C部分(SCWT-C)、言語流暢性測試(VFT)、連線測試A部分和連線測試B部分(TMT-A、B)、畫鐘測驗(CDT);進行頭顱MRI檢查,測算執(zhí)行功能相關(guān)腦區(qū)白質(zhì)部分各向異性(FA)值。結(jié)果對照組治療前后各項執(zhí)行功能測試成績差異無統(tǒng)計學(xué)意義。觀察組FNS治療后SCWT-C、VFT、TMT-A及TMT-B、CDT的測試成績較治療前有所提高(P均0.05),且觀察組治療后各項執(zhí)行功能測試成績優(yōu)于對照組治療后(P均0.05)。對照組治療前后執(zhí)行功能相關(guān)腦區(qū)白質(zhì)FA值差異無統(tǒng)計學(xué)意義。觀察組治療后右額葉白質(zhì)、左額葉白質(zhì)、右頂葉白質(zhì)、左頂葉白質(zhì)、右扣帶束、左扣帶束的FA值均高于治療前,且高于對照組治療后(P均0.05)。結(jié)論 FNS治療可提高LA患者的執(zhí)行功能,改善執(zhí)行功能相關(guān)腦區(qū)皮層下白質(zhì)纖維微結(jié)構(gòu)的完整性。
[Abstract]:Objective to observe the effect of cerebellar fastigial nucleus stimulation (FNS) on executive function in patients with white matter osteoporosis (LA). Methods 33 patients with LA with executive dysfunction were randomly divided into observation group (n = 17) and control group (n = 16). Both groups were treated with routine drugs, including brain protein hydrolysate for LA, symptomatic treatment for basic diseases, treatment for 20 days. On the basis of routine treatment, the patients in the observation group were treated with FNS. The cerebellar fastigial nucleus was stimulated by bionic electrical stimulation. The current was 1 Ma, the frequency was 130 鈮，

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