責(zé)任性顱內(nèi)動(dòng)脈粥樣硬化性狹窄致首發(fā)缺血性腦卒中解剖模式與發(fā)病機(jī)制的關(guān)系
發(fā)布時(shí)間：2019-05-13 20:15
【摘要】：目的探討責(zé)任性顱內(nèi)動(dòng)脈粥樣硬化性狹窄(Intracranial atherosclerotic stenosis,ICAS)致首發(fā)缺血性腦卒中(Ischemic stroke,IS)解剖模式與發(fā)病機(jī)制的關(guān)系。方法回顧性分析261例責(zé)任性ICAS致首發(fā)IS患者的臨床資料。根據(jù)彌散加權(quán)成像(DWI)的影像學(xué)表現(xiàn)分為單發(fā)病灶(皮質(zhì)-皮質(zhì)下梗死、皮質(zhì)梗死、皮質(zhì)下梗死),彌散病灶,多發(fā)病灶(單側(cè)前循環(huán)或后循環(huán)多發(fā)梗死);卒中機(jī)制分為動(dòng)脈到動(dòng)脈栓塞、原位血栓形成、穿支動(dòng)脈閉塞、低灌注、多發(fā)機(jī)制等。結(jié)果單發(fā)皮質(zhì)下梗死是責(zé)任性ICAS致首發(fā)IS最常見的卒中模式(41.38%,108/261);責(zé)任性ICAS致IS主要發(fā)病機(jī)制為穿支動(dòng)脈閉塞(41.38%,108/261);責(zé)任性ICAS致IS的解剖模式與發(fā)病機(jī)制顯著相關(guān)(r=0.384,P=0.001),穿支動(dòng)脈閉塞與皮質(zhì)下梗死相關(guān)(r=0.805,P=0.001),彌散梗死、單側(cè)前循環(huán)多發(fā)梗死、后循環(huán)多發(fā)性梗死,分別與動(dòng)脈到動(dòng)脈栓塞(r=0.853,P=0.001;r=0.860,P=0.001;r=0.281,P=0.001)、及多發(fā)機(jī)制(r=0.792,P=0.001;r=0.883,P=0.001;r=0.213,P=0.001)相關(guān)。結(jié)論卒中解剖模式有助于明確責(zé)任性ICAS致缺血性腦卒中的發(fā)病機(jī)制,有利于指導(dǎo)其臨床診治及預(yù)防措施的擬定。
[Abstract]:Objective to investigate the relationship between anatomical pattern and pathogenesis of primary ischemic stroke (Ischemic stroke,IS) caused by responsible intracranial atherosclerotic stenosis (Intracranial atherosclerotic stenosis,ICAS). Methods the clinical data of 261patients with IS caused by responsible ICAS were analyzed retrospectively. According to the imaging findings of diffusion-weighted imaging (DWI), they were divided into single focus (subcortical infarction, subcortical infarction), diffusion focus and multiple focus (unilateral anterior circulation or posterior circulation multiple infarction). The mechanism of stroke can be divided into artery to artery embolism, thrombosis in situ, occlusion of perforator artery, hypoperfusion, multiple mechanism and so on. Results single subcortical infarction was the most common stroke pattern of IS caused by responsible ICAS (41.38%, 108%), and the main pathogenesis of IS caused by responsible ICAS was perforating artery occlusion (41.38%, 108%). The anatomical pattern of IS induced by responsible ICAS was significantly correlated with the pathogenesis (r 鈮，
本文編號(hào)：2476160
[Abstract]:Objective to investigate the relationship between anatomical pattern and pathogenesis of primary ischemic stroke (Ischemic stroke,IS) caused by responsible intracranial atherosclerotic stenosis (Intracranial atherosclerotic stenosis,ICAS). Methods the clinical data of 261patients with IS caused by responsible ICAS were analyzed retrospectively. According to the imaging findings of diffusion-weighted imaging (DWI), they were divided into single focus (subcortical infarction, subcortical infarction), diffusion focus and multiple focus (unilateral anterior circulation or posterior circulation multiple infarction). The mechanism of stroke can be divided into artery to artery embolism, thrombosis in situ, occlusion of perforator artery, hypoperfusion, multiple mechanism and so on. Results single subcortical infarction was the most common stroke pattern of IS caused by responsible ICAS (41.38%, 108%), and the main pathogenesis of IS caused by responsible ICAS was perforating artery occlusion (41.38%, 108%). The anatomical pattern of IS induced by responsible ICAS was significantly correlated with the pathogenesis (r 鈮，
本文編號(hào)：2476160
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