非典型腦膜瘤38例療效及預后因素分析
發(fā)布時間:2019-05-12 05:37
【摘要】:目的探討非典型腦膜瘤治療療效及影響預后相關因素。方法回顧性分析38例非典型腦膜瘤患完整的臨床資料及隨訪資料,均行外科切除術,并參照2007年WHO腦腫瘤分類中非典型腦膜瘤病理診斷標準確診,其中男14例,女24例,年齡31~72歲,中位年齡53.5歲,手術前KPS評分40~90分,中位KPS 80分;凸面腦膜瘤21例,顱底腦膜瘤5例,大腦鐮旁和矢狀竇旁腦膜瘤10,其他2例;SimpsonⅠ級切除15例,SimpsonⅡ級切除9例,SimpsonⅢ級切除6例,SimpsonⅣ級切除8例;術后行3D-CRT放療12例,處方劑量Dt 50~60 Gy中位Dt 54 Gy。采用Kaplam-Meier進行生存分析,log-rank進行差異性檢驗。結(jié)果截至2017年4月,38例患者隨訪16~108個月,中位隨訪時間24.5個月,隨訪期間6例復發(fā),2例死亡;全組中位無進展生存時間(PFS)66個月,5年PFS 53.3%,5年OS 80.0%;單因素分析結(jié)果患者PFS與性別(女vs男,P=0.023)、年齡(年齡50歲vs年齡≥50歲,P=0.034)、Simpson分級(SimpsonⅠ級vsⅡ~Ⅳ級,P=0.028)相關,而與KPS(KPS≥80 vs KPS80,P=0.338)、病灶位置(凸面vs非凸面,P=0.201)、術后放療(放療vs非放療,P=0.456)無關。結(jié)論非典型腦膜瘤治療依然以外科手術為主,女性、年齡50歲、SimpsonⅠ級切除為延長PFS有利因素,但術后輔助放療并未改善PFS。
[Abstract]:Objective to investigate the therapeutic effect and prognostic factors of atypical meningioma. Methods the complete clinical data and follow-up data of 38 patients with atypical meningioma were analyzed retrospectively. all of them underwent surgical resection and were diagnosed according to the pathological diagnostic criteria of WHO classification of brain tumors in 2007, including 14 males and 24 females. The age was 31 鈮,
本文編號:2475148
[Abstract]:Objective to investigate the therapeutic effect and prognostic factors of atypical meningioma. Methods the complete clinical data and follow-up data of 38 patients with atypical meningioma were analyzed retrospectively. all of them underwent surgical resection and were diagnosed according to the pathological diagnostic criteria of WHO classification of brain tumors in 2007, including 14 males and 24 females. The age was 31 鈮,
本文編號:2475148
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