【摘要】：目的探討急性腦梗死患者血清血小板白細(xì)胞聚集體與動(dòng)脈粥樣硬化斑塊的關(guān)系。方法選擇腦梗死患者110例,根據(jù)高分辨率MRI對(duì)頸動(dòng)脈和大腦中動(dòng)脈評(píng)估結(jié)果分為易損斑塊組24例,穩(wěn)定斑塊組56例,無(wú)斑塊組30例,另選擇健康體檢者30例(對(duì)照組)。比較各組血小板白細(xì)胞聚集體、血小板單核細(xì)胞聚集體、血小板中性粒細(xì)胞聚集體、血小板淋巴細(xì)胞聚集體水平。結(jié)果易損斑塊組、穩(wěn)定斑塊組、無(wú)斑塊組血清血小板白細(xì)胞聚集體、血小板單核細(xì)胞聚集體、血小板粒細(xì)胞聚集體、血小板淋巴細(xì)胞聚集體水平明顯高于對(duì)照組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。易損斑塊組和穩(wěn)定斑塊組血清血小板白細(xì)胞聚集體、血小板單核細(xì)胞聚集體水平明顯高于無(wú)斑塊組,差異有統(tǒng)計(jì)學(xué)意義(P0.05)。與穩(wěn)定斑塊組比較,易損斑塊組血小板單核細(xì)胞聚集體水平明顯升高,差異有統(tǒng)計(jì)學(xué)意義[(31.34±6.18)%vs(24.67±5.34)%,P0.05]。結(jié)論血小板白細(xì)胞聚集體與動(dòng)脈粥樣硬化斑塊有關(guān),而血小板單核細(xì)胞聚集體與斑塊易損性密切相關(guān),可作為斑塊易損性指標(biāo)。
[Abstract]:Objective to investigate the relationship between platelet leukocyte aggregation and atherosclerotic plaque in patients with acute cerebral infarction (ACI). Methods 110 patients with cerebral infarction were divided into vulnerable plaque group (n = 24), stable plaque group (n = 56), non-plaque group (n = 30) and control group (n = 30) according to the evaluation results of carotid artery and middle cerebral artery by high resolution MRI. The levels of platelet leukocyte aggregation, platelet monocyte aggregation, platelet neutrophil aggregation and platelet lymphocyte aggregation were compared. Results the levels of platelet leukocyte aggregation, platelet monocyte aggregation, platelet granulocyte aggregation and platelet lymphocyte aggregation in vulnerable plaque group, stable plaque group and non-plaque group were significantly higher than those in control group. The difference was statistically significant (P0.05). The levels of platelet leukocyte aggregation and platelet monocyte aggregation in vulnerable plaque group and stable plaque group were significantly higher than those in non-plaque group (P0.05). Compared with stable plaque group, platelet monocyte aggregation level in vulnerable plaque group was significantly higher than that in stable plaque group [(31.34 鹵6.18)% vs (24.67 鹵5.34)%, P0.05]. Conclusion Platelet leukocyte aggregation is associated with atherosclerotic plaque, and platelet monocyte aggregation is closely related to plaque vulnerability, which can be used as an indicator of plaque vulnerability.
【作者單位】： 福建醫(yī)科大學(xué)附屬龍巖第一醫(yī)院神經(jīng)內(nèi)科;
【分類號(hào)】：R743.33
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本文編號(hào)：2454110