【摘要】：目的探討急性腦梗死患者血清膽堿酯酶活性與腦梗死的相關(guān)性。 方法選取在我院住院的201例急性腦梗死患者,將腦梗死組分為非大面積腦梗死組、大面積腦梗死組兩組,其中非大面積腦梗死組190例,大面積腦梗死組11例。選取體檢中心健康人37例為正常對(duì)照組。對(duì)腦梗死組與正常對(duì)照組的血清膽堿酯酶及血脂、血糖進(jìn)行檢測(cè)。并采用統(tǒng)計(jì)學(xué)軟件對(duì)實(shí)驗(yàn)結(jié)果進(jìn)行統(tǒng)計(jì)學(xué)意義的分析。 結(jié)果非大面積腦梗死組膽堿酯酶活性為(11083.33±1968.28)U/L,大面積腦梗死組膽堿酯酶活性為(6844.16±2270.41)U/L,對(duì)照組膽堿酯酶活性為(9570.59±1641.25)U/L,非大面積腦梗死組膽堿酯酶較對(duì)照組升高(P=0.000),大面積梗死組膽堿酯酶較對(duì)照組降低(P=0.003)。根據(jù)多元線性回歸分析,血清膽堿酯酶與血糖,總膽固醇,甘油三酯呈顯著正相關(guān)(P0.05)。Logistic回歸分析提示,血清CHE活性與腦梗死發(fā)病密切相關(guān)(95%可信區(qū)間,P=0.000)。 結(jié)論血清CHE活性是血糖,甘油三酯,總膽固醇的影響因素,呈正相關(guān)。血清膽堿酯酶活性升高與腦梗死的發(fā)生相關(guān),大面積腦梗死患者血清膽堿酯酶活性降低,與病情嚴(yán)重程度相關(guān)。
[Abstract]:Objective to investigate the correlation between serum cholinesterase activity and cerebral infarction in patients with acute cerebral infarction. Methods 201 patients with acute cerebral infarction in our hospital were divided into two groups: non-large area cerebral infarction group, and large area cerebral infarction group, including 190 cases of non-large area cerebral infarction group and 11 cases of large area cerebral infarction group. Thirty-seven healthy persons in physical examination center were selected as normal control group. Serum cholinesterase, blood lipid and blood glucose were measured in cerebral infarction group and normal control group. Statistical software was used to analyze the statistical significance of the experimental results. Results the cholinesterase activity was (11083.33 鹵1968.28) U / L in the non-large area cerebral infarction group, (6844.16 鹵2270.41) U / L in the large area cerebral infarction group and (9570.59 鹵1641.25) U / L in the control group. The cholinesterase in non-large area cerebral infarction group was higher than that in control group (P < 0. 000), and the cholinesterase in large area infarction group was lower than that in control group (P < 0. 003). According to multiple linear regression analysis, serum cholinesterase was positively correlated with blood glucose, total cholesterol and triglyceride (P0.05). Logistic regression analysis showed that serum CHE activity was closely related to the incidence of cerebral infarction (95% confidence interval). (P _ 0.000). Conclusion Serum CHE activity is positively correlated with blood glucose, triglyceride and total cholesterol. The increase of serum cholinesterase activity was related to the occurrence of cerebral infarction and the decrease of serum cholinesterase activity in patients with large area cerebral infarction, which was related to the severity of the disease.
【學(xué)位授予單位】：青島大學(xué)
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R743.3

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