發(fā)布時間：2019-03-21 14:35

【摘要】：目的探討磁共振測量胼胝體徑線對兒童發(fā)育遲緩的評估價值。方法收集120例1~5歲發(fā)育遲緩兒童與120例年齡匹配的正常發(fā)育兒童的頭顱MRI資料,按照生長規(guī)律分為6個年齡組,在T_1WI正中矢狀面測量胼胝體膝部、體部、壓部厚度及胼胝體長度,比較各年齡組發(fā)育遲緩兒童與正常兒童胼胝體參數(shù)的差異,并通過受試者工作特征(ROC)曲線分析各參數(shù)的診斷臨界值。結(jié)果第1~4年齡組(1~3歲)發(fā)育遲緩兒童胼胝體膝部及體部較正常發(fā)育兒童變薄(P0.05),胼胝體長度及胼胝體壓部厚度在兩組之間無明顯差異;第5、6年齡組(3~5歲)胼胝體各項參數(shù)在病例組與對照組間無明顯差異。通過ROC曲線分析第1~4年齡組胼胝體膝部厚度臨界值分別為8.1mm、7.5mm、8.9mm、9.2mm,敏感度分別為85.0%、60.0%、75.0%、60.0%,特異度分別為55.0%、95.0%、75.0%、85.0%;胼胝體體部厚度臨界值為4.3mm、4.3mm、4.5mm、4.7mm,敏感度分別為65.0%、75.0%、75.0%、50%,特異度分別為80.0%、65.0%、95.0%、90.0%。結(jié)論胼胝體膝部及體部的厚度可反映1~3歲發(fā)育遲緩兒童腦白質(zhì)體積變化,胼胝體徑線測量有助于該年齡段兒童的發(fā)育評估。
[Abstract]:Objective to evaluate the value of magnetic resonance imaging (MRI) in measuring the diameter of corpus callosum in children with stunted growth. Methods the cranial MRI data of 120 children with 1-5-year-old stunting and 120 age-matched normal children were collected and divided into 6 age groups according to the growth pattern. The corpus callosum knee and body were measured on the median sagittal plane of T_1WI. The thickness of the callosum and the length of corpus callosum were compared between the stunted children and the normal children. The diagnostic critical values of the parameters were analyzed by the (ROC) curve of the subjects' operating characteristics. Results the length of corpus callosum and the thickness of corpus callosum pressure were not significantly different between the first and fourth age groups (1 ~ 4 years old) compared with the normal children (P0.05), and the length of corpus callosum and the thickness of corpus callosum pressure were not significantly different between the two groups. There was no significant difference in the parameters of corpus callosum in the 5th and 6th age groups (3 to 5 years old) between the patient group and the control group. According to ROC curve analysis, the critical thickness of the corpus callosum knee was 8.1 mm, 7.5 mm, 8.9 mm, 9.2 mm, the sensitivity was 85.0%, 60.0%, 75.0%, 60.0%, 60.0%, respectively. The specificity was 55. 0%, 95. 0%, 75. 0%, 85. 0%, respectively. The critical values of corpus callosum thickness were 4.3 mm, 4.3 mm, 4.5 mm, 4.7 mm, respectively. The sensitivity was 65.0%, 75.0%, 75.0% and 50%, respectively. The specificity was 80.0%, 65.0%, 95.0% and 90.0%, respectively. Conclusion the thickness of the geniculus and body of corpus callosum can reflect the changes of white matter volume in 3-year-old children with stunted growth. The measurement of corpus callosum diameter is helpful to evaluate the development of children in this age group.
【作者單位】： 南通大學(xué)附屬南通市婦幼保健院醫(yī)學(xué)影像科;
【分類號】：R748;R445.2

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