常德市漢族居民頸動脈粥樣硬化斑塊穩(wěn)定性的相關因素分析
發(fā)布時間：2019-03-17 12:46
【摘要】：目的探討影響常德市漢族居民頸動脈粥樣硬化(CAS)斑塊穩(wěn)定性的相關因素。方法回顧性分析2014年1月至2014年12月期間在常德市第一人民醫(yī)院門診部就診和體檢中心進行體檢的符合入組標準的對象794例,將入組對象分為穩(wěn)定斑塊組(353例)和不穩(wěn)定斑塊組(441例)。收集一般資料及生化檢測結(jié)果。根據(jù)頸部血管彩色多普勒檢查結(jié)果,對兩組資料進行比較分析。結(jié)果單因素分析顯示,兩組在高血壓、糖尿病、吸煙、年齡、總膽固醇(TC)、低密度脂蛋白膽固醇(LDL-C)、高密度脂蛋白膽固醇(HDL-C)、纖維蛋白原(FIB)、C-反應蛋白(CRP)和同型半胱氨酸(Hcy)指標上差異有統(tǒng)計學意義(P0.05)。多因素Logistic回歸分析顯示,糖尿病(OR=3.115,95%CI:2.163~4.487,P=0.000)、高血壓(OR=1.991,95%CI:1.429~2.772,P=0.000)、吸煙(OR=1.372,95%CI:1.001~1.879,P=0.049)、LDL-C(OR=1.308,95%CI:1.084~1.578,P=0.005)、FIB(OR=1.291,95%CI:1.055~1.580,P=0.013)、TC(OR=1.216,95%CI:1.001~1.477,P=0.049)、年齡(OR=1.033,95%CI:1.017~1.048,P=0.000)和Hcy(OR=1.031,95%CI:1.009~1.053,P=0.006)是CAS不穩(wěn)定斑塊形成的危險因素,差異具有統(tǒng)計學意義(P0.05)。HDL-C(OR=0.447,95%CI:0.270~0.740,P=0.002)是CAS不穩(wěn)定斑塊形成的保護因素,差異具有統(tǒng)計學意義(P0.05)。結(jié)論糖尿病、高血壓、吸煙、LDL-C、FIB、TC、Hcy和年齡是常德市漢族居民CAS不穩(wěn)定斑塊的危險因素,HDL-C是常德市漢族居民CAS斑塊穩(wěn)定性的保護因素。
[Abstract]:Objective to investigate the influencing factors of (CAS) plaque stability of carotid atherosclerosis in Han nationality of Changde. Methods from January 2014 to December 2014, 794 patients who met the criteria of medical examination in the outpatient department and physical examination center of the first people's Hospital of Changde City were analyzed retrospectively. The subjects were divided into stable plaque group (353 cases) and unstable plaque group (441 cases). Collect general data and biochemical test results. According to the results of color Doppler, the data of the two groups were compared and analyzed. Results univariate analysis showed that in hypertension, diabetes, smoking, age, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fibrinogen (FIB),. There was significant difference between C-reactive protein (CRP) and homocysteine (Hcy) (P0.05). Multivariate Logistic regression analysis showed that diabetes mellitus (OR=3.115,95%CI:2.163~4.487,P=0.000), hypertension (OR=1.991,95%CI:1.429~2.772,P=0.000), smoking (OR=1.372,95%CI:1.001~1.879,P=0.049), LDL-C (OR=1.308,95%CI:1.084~1.578,P=0.005), FIB (OR=1.291,95%CI:1.055~1.580,P=0.013), TC (OR=1.216,95%CI:1.001~1.477,P=0.049), age (OR=1.033,95%CI:1.017~1.048,) P < 0. 000) and Hcy (OR=1.031,95%CI:1.009~1.053,P=0.006) were the risk factors of unstable plaque formation in CAS, the difference was statistically significant (P0.05). HDL-C (OR=0.447,95%CI:0.270~0.740,) P0. 002) was the protective factor of CAS unstable plaque formation, the difference was statistically significant (P0.05). Conclusion Diabetes mellitus, hypertension, smoking, LDL-C,FIB,TC,Hcy and age are risk factors for unstable plaque of CAS in Han nationality of Changde, and HDL-C is a protective factor of stability of CAS plaque of Han nationality of Changde.
【作者單位】： 常德市第一人民醫(yī)院神經(jīng)內(nèi)科;中南大學湘雅醫(yī)院神經(jīng)內(nèi)科;
【分類號】：R743.3
[Abstract]:Objective to investigate the influencing factors of (CAS) plaque stability of carotid atherosclerosis in Han nationality of Changde. Methods from January 2014 to December 2014, 794 patients who met the criteria of medical examination in the outpatient department and physical examination center of the first people's Hospital of Changde City were analyzed retrospectively. The subjects were divided into stable plaque group (353 cases) and unstable plaque group (441 cases). Collect general data and biochemical test results. According to the results of color Doppler, the data of the two groups were compared and analyzed. Results univariate analysis showed that in hypertension, diabetes, smoking, age, total cholesterol (TC), low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C), fibrinogen (FIB),. There was significant difference between C-reactive protein (CRP) and homocysteine (Hcy) (P0.05). Multivariate Logistic regression analysis showed that diabetes mellitus (OR=3.115,95%CI:2.163~4.487,P=0.000), hypertension (OR=1.991,95%CI:1.429~2.772,P=0.000), smoking (OR=1.372,95%CI:1.001~1.879,P=0.049), LDL-C (OR=1.308,95%CI:1.084~1.578,P=0.005), FIB (OR=1.291,95%CI:1.055~1.580,P=0.013), TC (OR=1.216,95%CI:1.001~1.477,P=0.049), age (OR=1.033,95%CI:1.017~1.048,) P < 0. 000) and Hcy (OR=1.031,95%CI:1.009~1.053,P=0.006) were the risk factors of unstable plaque formation in CAS, the difference was statistically significant (P0.05). HDL-C (OR=0.447,95%CI:0.270~0.740,) P0. 002) was the protective factor of CAS unstable plaque formation, the difference was statistically significant (P0.05). Conclusion Diabetes mellitus, hypertension, smoking, LDL-C,FIB,TC,Hcy and age are risk factors for unstable plaque of CAS in Han nationality of Changde, and HDL-C is a protective factor of stability of CAS plaque of Han nationality of Changde.
【作者單位】： 常德市第一人民醫(yī)院神經(jīng)內(nèi)科;中南大學湘雅醫(yī)院神經(jīng)內(nèi)科;
【分類號】：R743.3
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