【摘要】：目的顱內(nèi)靜脈竇血栓形成(CVST)誤診率較高,而關(guān)于CVST診斷時間與患者臨床特征及預(yù)后之間的相關(guān)性研究較少,文中旨在探討CVST患者的臨床特征與其診斷時間長短之間的關(guān)系,并分析延遲診斷對患者預(yù)后的影響。方法回顧性分析2004年3月至2016年8月南京軍區(qū)南京總醫(yī)院神經(jīng)內(nèi)科收治的94例CVST住院患者臨床資料。根據(jù)四分位診斷時間將患者分為5 d組、5~9 d組、10~16 d組、16 d組,主要研究終點是患者出院后3個月的改良RANKIN量表(modified Rankin Scale scorem,mRS)評分≤1分,次要研究終點是患者出院后3個月的mRS評分≤2分。并分析CVST患者延遲診斷時間與臨床特征之間的相互關(guān)系。結(jié)果 CVST延遲診斷時間與視乳頭水腫、孤立性顱內(nèi)高壓綜合征、癲癇、顱內(nèi)病灶、GCS評分有關(guān)(P0.05);視乳頭水腫、孤立性顱內(nèi)高壓綜合征、GCS評分14~15分需要更長的診斷時間;癲癇、存在腦出血或梗塞病灶所需診斷時間較短。實驗室指標中,低清蛋白水平、低總蛋白水平、高凝血酶時間、及高C反應(yīng)蛋白水平的患者所需診斷時間較短(P0.05)。延遲診斷時間的長短與CVST患者的mRS評分沒有相關(guān)性(P0.05)。結(jié)論為避免延遲診斷可以以CVST患者入院時的癥狀及實驗室指標為體征及標志物,為指導臨床CVST的早期診斷提供新的參考。
[Abstract]:Objective the misdiagnosis rate of intracranial venous sinus thrombosis (CVST) is high, but the correlation between the diagnosis time of CVST and the clinical characteristics and prognosis of the patients is less studied. The purpose of this paper is to explore the relationship between the clinical characteristics and the duration of diagnosis of CVST patients. The effect of delayed diagnosis on prognosis was analyzed. Methods from March 2004 to August 2016, the clinical data of 94 inpatients with CVST in Department of Neurology, Nanjing General Hospital of Nanjing military region were retrospectively analyzed. According to the diagnostic time of quartile, the patients were divided into 5 d group, 5 d group, 10 d group, 16 d group. The main end point of the study was the modified RANKIN scale (modified Rankin Scale scorem,mRS) score 鈮，

本文編號：2420064