【摘要】：目的：探討貴州省貴陽(yáng)、遵義、都勻等地炎性神經(jīng)系統(tǒng)疾病中博爾納病病毒(Bornadisease virus，BDV)感染情況和主要感染方式，以及病毒性腦炎BDV CIC陽(yáng)性患者的臨床特征。 方法：采用酶聯(lián)免疫吸附試驗(yàn)（ELISA）檢測(cè)84例炎性神經(jīng)系統(tǒng)疾病患者，包括69例病毒性腦炎（VE）患者，9例格林 巴利綜合征（GBS）患者，6例多發(fā)性硬化（MS）患者，以及45例對(duì)照組(非炎癥性神經(jīng)系統(tǒng)疾病患者)腦脊液（CSF）中BDV循環(huán)免疫復(fù)合物（CIC）及抗體，對(duì)腦脊液BDV CIC陽(yáng)性患者取其外周血同期行血液BDV CIC檢測(cè)。 結(jié)果：84例炎性神經(jīng)系統(tǒng)疾病患者CSF中BDV CIC總陽(yáng)性率為15.40%(13/84)，其中VE陽(yáng)性率14.40％（10/69），GBS陽(yáng)性率11.10％(1/9)，，MS陽(yáng)性率33.30％(2/6)，對(duì)照組陽(yáng)性率2.22％(1/45)，實(shí)驗(yàn)組總體陽(yáng)性率明顯高于對(duì)照組（P＜0.05），兩組比較差異具有統(tǒng)計(jì)學(xué)意義。CSF抗體總體陽(yáng)性率1.20％(1/84)，對(duì)照組抗體陽(yáng)性率為0，兩組比較差異無(wú)統(tǒng)計(jì)學(xué)意義（P＞0.05）。13例腦脊液BDV CIC陽(yáng)性患者，外周血BDV CIC陽(yáng)性者10例，陽(yáng)性程度高于腦脊液。7例腦脊液BDV CIC陽(yáng)性病毒性腦炎患者主要以精神行為異常為特征，患者有密切動(dòng)物接觸史。 結(jié)論：貴州省貴陽(yáng)、遵義、都勻等地在炎性神經(jīng)系統(tǒng)疾病患者中存在BDV感染；BDV特異性CIC陽(yáng)性VE患者主要以精神行為異常為臨床特征；BDV感染方式以隱性感染為主，隱性感染的患者可能超出顯性感染者的比例；BDV與人類的密切關(guān)系可能較高。
[Abstract]:Objective: to investigate the infection of Borna disease virus (Bornadisease virus,BDV) in inflammatory nervous system diseases in Guiyang, Zunyi and Duyun, Guizhou Province, and the clinical characteristics of BDV CIC positive patients with viral encephalitis. Methods: Enzyme-linked immunosorbent assay (ELISA) was used to detect 84 patients with inflammatory nervous system diseases, including 69 patients with viral encephalitis (VE), 9 patients with Guillain-Barre syndrome (GBS) and 6 patients with multiple sclerosis (MS). BDV circulating immune complex (CIC) and antibody in cerebrospinal fluid (CSF) were collected from 45 patients with BDV CIC positive cerebrospinal fluid (BDV CIC) in cerebrospinal fluid (CSF). Results: the total positive rate of BDV CIC in CSF of 84 patients with inflammatory nervous system diseases was 15.40% (13 / 84), and the positive rate of VE was 14.40% (10 / 69), GBS) 11.10% (1 / 9). The positive rate of MS was 33.30% (2 / 6) and the positive rate of control group was 2.22% (1 / 45). The total positive rate of experimental group was significantly higher than that of control group (P < 0. 05). The total positive rate of CSF antibody was 1.20% (1 / 84), while the positive rate of control group was 0. There was no significant difference between the two groups (P > 0. 05). The positive degree of BDV CIC in peripheral blood was higher in 10 cases than that in cerebrospinal fluid (CSF). 7 cases of BDV CIC positive viral encephalitis were mainly characterized by abnormal mental behavior and had close animal contact history. Conclusion: in Guiyang, Zunyi and Duyun of Guizhou Province, there is BDV infection in patients with inflammatory nervous system diseases, and the main clinical features of VE patients with BDV specific CIC are abnormal mental behavior. Recessive infection is the main mode of BDV infection, and the proportion of patients with recessive infection may be higher than that of dominant infection, and the close relationship between BDV and human may be higher.
【學(xué)位授予單位】：遵義醫(yī)學(xué)院
【學(xué)位級(jí)別】：碩士
【學(xué)位授予年份】：2014
【分類號(hào)】：R741

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