【摘要】：目的:分析總結(jié)25例成人丘腦惡性神經(jīng)膠質(zhì)瘤臨床特點(diǎn)。方法:回顧性分析2011—2016年首都醫(yī)科大學(xué)附屬北京世紀(jì)壇醫(yī)院腦膠質(zhì)瘤科收治的病理明確的25例成人丘腦膠質(zhì)瘤患者,記錄患者的癥狀持續(xù)時(shí)間、Karnofsky(KPS)評分、臨床癥狀、治療情況、無進(jìn)展生存時(shí)間(PFS)和總生存時(shí)間(OS)。COX回歸進(jìn)行生存分析。結(jié)果:患者癥狀包括頭暈頭痛、肢體運(yùn)動障礙、肢體感覺障礙、視力障礙、惡心嘔吐、癲癇、記憶力下降和面癱。11例患者行立體定向活檢,14例患者行部分或近全手術(shù)切除,20例患者接受了同步放化療和替莫唑胺化療,25例患者的中位生存期為21.1個(gè)月(9.4~47.7個(gè)月),中位PFS 15.0個(gè)月(1.3~30.1個(gè)月)。多因素分析顯示,癥狀持續(xù)時(shí)間(P=0.002)和KPS(P=0.003)是本組患者OS的獨(dú)立預(yù)后因素。結(jié)論:癥狀持續(xù)時(shí)間超過2個(gè)月和KPS≥70分的患者預(yù)后較好。手術(shù)聯(lián)合放化療等綜合治療是成人丘腦膠質(zhì)瘤主要的治療方案。
[Abstract]:Objective: to analyze and summarize the clinical features of 25 adult thalamic malignant gliomas. Methods: a total of 25 adult patients with thalamic gliomas treated in the Department of glioma, Beijing Century altar Hospital, affiliated to Capital Medical University, from 2011 to 2016, were retrospectively analyzed. The symptom duration (, Karnofsky (KPS) score and clinical symptoms were recorded. Survival analysis was performed by (PFS) and total survival time (OS). COX) regression. Results: the symptoms included dizziness and headache, dyskinesia, sensory impairment, visual impairment, nausea and vomiting, epilepsy, memory loss and facial paralysis, 11 patients underwent stereotactic biopsy, 14 patients underwent partial or subtotal resection. The median survival time was 21.1 months (9.4 ~ 47.7 months) and 15.0 months (1.3 鹵30.1 months) in 25 patients. Multivariate analysis showed that the duration of symptoms (P0. 002) and KPS (P0. 003) were independent prognostic factors of OS. Conclusion: the prognosis of patients with symptoms lasting more than 2 months and KPS 鈮，

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