【摘要】：目的：探討腦血管支架置入術(shù)后再狹窄的影響因素、治療措施及預(yù)防。方法：回顧性分析120例腦血管支架置入術(shù)后患者臨床資料,CTA或DSA隨訪6-12月(平均9個月),根據(jù)出現(xiàn)支架部位分為頸內(nèi)動脈支架組(74例)及椎動脈支架組(46例),各組根據(jù)是否出現(xiàn)狹窄分為再狹窄組和未狹窄組,其中頸內(nèi)動脈支架組再狹窄組(10例)和未狹窄組(64例),椎動脈支架組再狹窄組(21例)和未狹窄組(25例)。分析支架置入后再狹窄是否與支架類型、高血壓、糖尿病、規(guī)律服用抗血小板凝集藥物等因素的相關(guān)性。結(jié)果：椎動脈支架置入術(shù)后再狹窄組與未狹窄組中高密度脂蛋白(t=2.24,P0.05),患有糖尿病為9例和5例(χ2=4.06,P0.05)。甘油三酯、低密度脂蛋白、冠心病、高血壓、吸煙、飲酒等危險因素對椎動脈支架均無統(tǒng)計學(xué)意義。頸內(nèi)動脈支架置入術(shù)后再狹窄組與未狹窄組,患有冠心病為1例和4例(χ2=20.08,P0.05)。甘油三脂、低密度脂蛋白、高密度脂蛋白、高血壓、糖尿病、飲酒、吸煙等危險因素對頸內(nèi)動脈支架均無統(tǒng)計學(xué)意義。術(shù)后3-6個月內(nèi)規(guī)律抗血小板凝集治療與支架內(nèi)再狹窄有關(guān)。結(jié)論：椎動脈支架置入術(shù)后再狹窄與是否與患有糖尿病及高密度脂蛋白有關(guān),頸內(nèi)動脈支架置入術(shù)后再狹窄與冠心病有關(guān)。支架內(nèi)再狹窄與是否規(guī)律服用抗血小板凝集藥物有關(guān)。椎動脈支架內(nèi)再狹窄率高于頸內(nèi)動脈支架再狹窄率。其他相關(guān)因素有待進一步研究。
[Abstract]:Objective: to investigate the influencing factors, treatment and prevention of restenosis after cerebrovascular stent implantation. Methods: the clinical data of 120 patients after cerebrovascular stenting were retrospectively analyzed. CTA or DSA were followed up for 6-12 months (mean 9 months). According to the location of stents, they were divided into internal carotid artery stent group (74 cases) and vertebral artery stent group (46 cases). Each group was divided into restenosis group (n = 10) and non-stenosis group (n = 64), restenosis group (n = 21) and non-stenosis group (n = 25). To analyze whether restenosis after stent placement is related to stent type, hypertension, diabetes mellitus, regular administration of antiplatelet agglutinin, and so on. Results: high density lipoprotein (HDL-C) was found in restenosis group and non-stenosis group after vertebral artery stenting, 9 cases and 5 cases with diabetes mellitus (蠂 2 / 4.06 P 0.05). Triglyceride, low density lipoprotein, coronary heart disease, hypertension, smoking, drinking and other risk factors had no statistical significance in vertebral artery stents. There were 1 case and 4 cases of coronary heart disease in restenosis group and non-stenosis group after internal carotid artery stenting (蠂 2 20.08 P 0.05). Triglyceride, low density lipoprotein, hypertension, diabetes, alcohol, smoking and other risk factors had no statistical significance in carotid artery stents. Regular anti-platelet agglutination was associated with stent restenosis 3-6 months after operation. Conclusion: restenosis after vertebral artery stenting is associated with diabetes mellitus and high density lipoprotein, and restenosis after internal carotid artery stenting is associated with coronary heart disease. Stent restenosis is associated with regular administration of antiplatelet agglutinants. The rate of in-stent restenosis in vertebral artery was higher than that in internal carotid artery. Other relevant factors need further study.
【學(xué)位授予單位】：新疆醫(yī)科大學(xué)
【學(xué)位級別】：碩士
【學(xué)位授予年份】：2014
【分類號】：R743

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