帕瑞昔布鈉對急性腦梗死患者療效、炎癥指標及腎功能的影響
發(fā)布時間:2018-12-17 17:34
【摘要】:目的探討帕瑞昔布鈉對急性腦梗死(ACI)患者療效、炎癥指標及腎功能的影響。方法選擇ACI患者89例,隨機分為觀察組46例和對照組43例。兩組均給予常規(guī)治療及尿激酶溶栓治療,觀察組加用帕瑞昔布鈉治療。治療前及治療1周后,比較兩組患者的炎癥和腎功能指標水平、美國國立衛(wèi)生研究院卒中量表(NIHSS)評分、急性生理與慢性健康評估(APACHEⅡ)評分。結(jié)果治療后兩組的超敏C反應(yīng)蛋白、腫瘤壞死因子-α(TNF-α)、白細胞介素-6、胱抑素、血尿素氮、血清肌酐水平以及APACHEⅡ、NIHSS評分均較前降低(除外TNF-α,均P0.05),且觀察組以上指標均低于對照組(均P0.05)。結(jié)論帕瑞昔布鈉能夠改善ACI患者的神經(jīng)功能缺損情況及保護腎功能,其可能通過抑制炎癥介質(zhì)的大量釋放、控制炎癥反應(yīng)而實現(xiàn)。
[Abstract]:Objective to investigate the effect of paroxib sodium on (ACI) patients with acute cerebral infarction. Methods 89 patients with ACI were randomly divided into observation group (n = 46) and control group (n = 43). Both groups were treated with routine therapy and urokinase thrombolytic therapy. The inflammatory and renal function indexes, (NIHSS) score and APACHE 鈪,
本文編號:2384564
[Abstract]:Objective to investigate the effect of paroxib sodium on (ACI) patients with acute cerebral infarction. Methods 89 patients with ACI were randomly divided into observation group (n = 46) and control group (n = 43). Both groups were treated with routine therapy and urokinase thrombolytic therapy. The inflammatory and renal function indexes, (NIHSS) score and APACHE 鈪,
本文編號:2384564
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