【摘要】：目的探討顱內(nèi)動(dòng)脈瘤壁雌激素和雄激素受體表達(dá)水平的意義。方法前瞻性納入2007年11月至2016年6月在四川大學(xué)華西醫(yī)院接受開顱手術(shù)夾閉顱內(nèi)動(dòng)脈瘤的患者32例,獲得顱內(nèi)動(dòng)脈瘤壁19個(gè),顳淺動(dòng)脈分支26個(gè),共45個(gè)合格標(biāo)本。采用免疫組化法檢測(cè)顳淺動(dòng)脈分支和顱內(nèi)動(dòng)脈瘤壁平滑肌層及內(nèi)皮細(xì)胞的雌激素受體-α、β及雄激素受體表達(dá)水平。以Image Pro Plus6.0軟件分析檢測(cè)陽(yáng)性細(xì)胞表達(dá)水平積分光密度值。統(tǒng)計(jì)學(xué)分析采用χ2檢驗(yàn),成組Mann-Whitney秩和檢驗(yàn)。結(jié)果動(dòng)脈瘤壁的雌激素受體-α、β表達(dá)中位數(shù)(M)與四分位距(P25,P75)分別為3 049(2 112,5 554)和4 364(2 314,5 667),低于顳淺動(dòng)脈分支的6 544(3 507,10 103)和6 972(5 694,10 024)。動(dòng)脈瘤壁雄激素受體表達(dá)水平3 299(1 375,4 895),高于顳淺動(dòng)脈分支的1 130(794,1 922),兩組比較差異均有統(tǒng)計(jì)學(xué)意義(均P0.05)。結(jié)論腦血管壁雌激素受體-α、β表達(dá)水平的降低,雄激素受體表達(dá)水平的升高,可能促進(jìn)了顱內(nèi)動(dòng)脈瘤的進(jìn)展,但具體機(jī)制尚需進(jìn)一步研究。
[Abstract]:Objective to investigate the expression of estrogen and androgen receptors in intracranial aneurysms. Methods Thirty-two patients with intracranial aneurysms underwent craniotomy from November 2007 to June 2016 in Huaxi Hospital of Sichuan University were included. Nineteen intracranial aneurysms and 26 branches of superficial temporal artery were obtained and 45 qualified specimens were obtained. The expression of estrogen receptor- 偽, 尾 and androgen receptor in smooth muscle layer and endothelial cells of the branches of superficial temporal artery and intracranial aneurysm were detected by immunohistochemical method. The integrated optical density of positive cells was measured by Image Pro Plus6.0 software. 蠂 2 test and Mann-Whitney rank sum test were used in statistical analysis. Results the median (M) and quartile distance of estrogen receptor- 偽 and 尾 expression in aneurysms were 3 049 (2 112 554) and 4 364 (2 314 5 667), respectively. It was lower than the branches of superficial temporal artery (6 544 (3 507) 10 103) and 6 972 (5 694) (10 024). The expression level of androgen receptor in aneurysm wall was 3 299 (1 375 ~ 4 895), which was higher than that in superficial temporal artery (1 130) (79 4 ~ 1 922). The difference between the two groups was statistically significant (P0.05). Conclusion the decrease of estrogen receptor-偽, 尾 expression level and the increase of androgen receptor expression may promote the development of intracranial aneurysms, but the specific mechanism needs to be further studied.
【作者單位】： 四川大學(xué)華西醫(yī)院神經(jīng)外科;德陽(yáng)市人民醫(yī)院神經(jīng)外科;
【基金】：四川省科技支撐計(jì)劃項(xiàng)目(2016SZ0015)
【分類號(hào)】：R743

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