大動(dòng)脈粥樣硬化型腦梗死患者TLR4基因多態(tài)性觀察
發(fā)布時(shí)間：2018-12-07 12:39
【摘要】：目的觀察中國(guó)膠東半島地區(qū)大動(dòng)脈粥樣硬化(LAA)型腦梗死漢族患者TLR4基因的rs1927911、rs1927914、rs2149356位點(diǎn)單核苷酸多態(tài)性情況。方法將LAA型腦梗死患者105例納入病例組,選擇同期健康體檢者125例納入對(duì)照組。采用PCR-RFLP法或直接測(cè)序法觀察兩組白細(xì)胞TLR4基因rs1927911、rs1927914、rs2149356位點(diǎn)的單核苷酸多態(tài)性情況。結(jié)果兩組各多態(tài)性位點(diǎn)的基因型和等位基因頻率均符合Hardy-Weinberg遺傳平衡定律(P0.05)。病例組TLR4基因rs1927911位點(diǎn)CC、TT基因型頻率低于對(duì)照組,CT基因型頻率高于對(duì)照組(P均0.05)。病例組rs2149356位點(diǎn)CC、AC基因型頻率低于對(duì)照組,AA基因型頻率高于對(duì)照組,A等位基因頻率高于對(duì)照組(P均0.05)。結(jié)論中國(guó)膠東半島地區(qū)LAA型腦梗死漢族患者白細(xì)胞TLR4基因rs1927911、rs2149356位點(diǎn)多態(tài)性可能與LAA型腦梗死的發(fā)病有關(guān)。
[Abstract]:Objective to observe the single nucleotide polymorphism (SNP) of TLR4 locus of TLR4 gene in patients with (LAA) type cerebral infarction in Jiaodong Peninsula. Methods 105 patients with LAA type cerebral infarction were included in the case group, and 125 healthy persons were included in the control group. Single nucleotide polymorphisms at rs1927911,rs1927914,rs2149356 site of TLR4 gene were observed by PCR-RFLP or direct sequencing. Results the genotypes and allelic frequencies of each polymorphism locus in the two groups were in accordance with the Hardy-Weinberg genetic balance law (P0.05). The frequency of CC,TT genotype at rs1927911 site of TLR4 gene was lower than that of control group, and the frequency of CT genotype was higher than that of control group (all P 0.05). The frequency of CC,AC genotype, AA genotype and A allele in rs2149356 locus were lower than those in control group (P < 0. 05). Conclusion the polymorphisms of TLR4 gene rs1927911,rs2149356 locus of leukocyte in Han nationality patients with LAA type cerebral infarction in Jiaodong Peninsula of China may be related to the pathogenesis of LAA type cerebral infarction.
【作者單位】： 青島大學(xué)醫(yī)學(xué)院第二附屬醫(yī)院;
【分類號(hào)】：R743.33
本文編號(hào)：2367219
[Abstract]:Objective to observe the single nucleotide polymorphism (SNP) of TLR4 locus of TLR4 gene in patients with (LAA) type cerebral infarction in Jiaodong Peninsula. Methods 105 patients with LAA type cerebral infarction were included in the case group, and 125 healthy persons were included in the control group. Single nucleotide polymorphisms at rs1927911,rs1927914,rs2149356 site of TLR4 gene were observed by PCR-RFLP or direct sequencing. Results the genotypes and allelic frequencies of each polymorphism locus in the two groups were in accordance with the Hardy-Weinberg genetic balance law (P0.05). The frequency of CC,TT genotype at rs1927911 site of TLR4 gene was lower than that of control group, and the frequency of CT genotype was higher than that of control group (all P 0.05). The frequency of CC,AC genotype, AA genotype and A allele in rs2149356 locus were lower than those in control group (P < 0. 05). Conclusion the polymorphisms of TLR4 gene rs1927911,rs2149356 locus of leukocyte in Han nationality patients with LAA type cerebral infarction in Jiaodong Peninsula of China may be related to the pathogenesis of LAA type cerebral infarction.
【作者單位】： 青島大學(xué)醫(yī)學(xué)院第二附屬醫(yī)院;
【分類號(hào)】：R743.33
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