新疆維吾爾族、漢族帕金森病PARK16基因多態(tài)性研究
[Abstract]:Objective: to investigate the relationship between the polymorphism of rs947211 and rs823144 loci of PARK16 gene and PD of Uygur nationality and Han nationality in Xinjiang, and to determine whether there are differences in the distribution of rs947211 and rs823144 loci between the two populations. Methods: PCR polymerase chain reaction and DNA sequencing were used to type 441 patients with PD (260 cases of Han nationality and 181 cases of Uygur nationality) and 495 healthy controls without PD (Han 287, Uygur 208). Results: (1) there were significant differences in genotype and allele frequency of rs947211 locus between PD group of Han nationality and control group of Han nationality. The risk of PD in G allele carriers was higher than that in non-carriers (OR=1.407,95%CI.1.108-1.788). There were significant differences in genotype and allele frequency between Uygur PD group and Uygur nationality control group (蠂 ~ 2 + 8.100) (蠂 ~ (2) = 8.100) and Z ~ (2 +) ~ (7.117) (P ~ (0. 008). G alleles were more likely to develop PD in Uighur carriers than non-carriers (OR=1.471,95%CI.1.107-1.955) of the same ethnic group. There was no significant difference in genotype and allele frequency between Han PD group and Uygur PD group (蠂 ~ 2 / 0. 053 / P ~ (0.974) and 蠂 ~ (2 +) ~ (0.013) P ~ (0.911). (_ 2) rs823144 locus in PD group and control group of Han nationality. There was no significant difference in genotype and allele frequency between Uygur PD group and Uygur control group, as well as between Han PD group and Uygur PD group (蠂 ~ (2) ~ (2) ~ (1) 1. 19% P ~ (0.68) and 蠂 ~ (2 +) ~ (1.592) P ~ (0.207); 蠂 ~ 2 ~ (2) ~ (0.325) ~ 0.850 and 蠂 ~ (2 +) ~ (0.173) P ~ (0.678) ~ (2.173) ~ (0.337) ~ (0.337) and ~ (2) ~ (2) ~ (2) ~ (3) ~ (15) ~ (1) ~ (0.128). Conclusion: the rs947211 polymorphism of PARK16 gene is associated with the occurrence of PD in Xinjiang Uygur and Han nationality. G allele may be one of the genetic markers of PD genetic susceptibility, but there is no significant difference between PD and PD in Uygur nationality. Rs823144 may not be associated with the occurrence of PD in Xinjiang Uygur and Han nationalities.
【學(xué)位授予單位】:新疆醫(yī)科大學(xué)
【學(xué)位級別】:碩士
【學(xué)位授予年份】:2014
【分類號】:R742.5
【相似文獻(xiàn)】
相關(guān)期刊論文 前10條
1 張凌志;;改良Park’s手術(shù)在低位直腸癌中的臨床應(yīng)用[J];中國醫(yī)療前沿;2009年17期
2 ;[J];;年期
3 ;[J];;年期
4 ;[J];;年期
5 ;[J];;年期
6 ;[J];;年期
7 ;[J];;年期
8 ;[J];;年期
9 ;[J];;年期
10 ;[J];;年期
相關(guān)重要報紙文章 前9條
1 本報記者 薛穎旦 江錫民 馬薇 王宏偉;Park經(jīng)濟:無錫優(yōu)化發(fā)展的精彩呈現(xiàn)[N];新華日報;2009年
2 本報記者 劉妮麗;751 D·PARK:老工廠上演時尚秀[N];中國文化報;2013年
3 本報記者 伍平;云南銀河T·PARK科技園“首秀”中關(guān)村論壇年會[N];云南科技報;2013年
4 記者 英潔;Park經(jīng)濟催生“智慧產(chǎn)業(yè)”高地[N];無錫日報;2009年
5 本版文字 新一 編譯;GiltGroupe推出男士奢侈品零售網(wǎng)站[N];中國服飾報;2011年
6 顧汶;E-PARK建設(shè)至關(guān)重要[N];中國高新技術(shù)產(chǎn)業(yè)導(dǎo)報;2004年
7 ;惠山軟件外包園(O—Park)[N];江蘇經(jīng)濟報;2011年
8 本報記者 李繼紅;產(chǎn)業(yè)綜合體的云南實踐[N];云南日報;2013年
9 本報記者 伍平;云南欲再造一座“中關(guān)村”[N];云南科技報;2013年
相關(guān)碩士學(xué)位論文 前1條
1 夏歡;新疆維吾爾族、漢族帕金森病PARK16基因多態(tài)性研究[D];新疆醫(yī)科大學(xué);2014年
,本文編號:2352347
本文鏈接:http://sikaile.net/yixuelunwen/shenjingyixue/2352347.html