【摘要】：目的觀察急性腦梗死患者腦紅蛋白(Ngb)、腦源性神經(jīng)營(yíng)養(yǎng)因子(BDNF)和髓鞘堿性蛋白(MBP)水平變化及其與病情嚴(yán)重程度和預(yù)后的關(guān)系。方法選擇我院2012年1月—2015年12月收治的急性腦梗死126例(腦梗死組)及同期在我院體檢健康的30例(對(duì)照組)。比較兩組血清Ngb、BDNF和MBP水平變化,觀察各指標(biāo)與神經(jīng)功能損傷程度、腦梗死面積和預(yù)后的關(guān)系及各指標(biāo)間的相關(guān)性。結(jié)果與對(duì)照組比較,腦梗死組血清Ngb和MBP明顯升高(P0.01),而BDNF則顯著降低(P0.01)。隨著神經(jīng)功能損傷程度的加重和腦梗死面積的增大,腦梗死組血清Ngb和MBP水平升高(P0.01),BDNF水平降低(P0.01)。腦梗死組預(yù)后良好者Ngb和MBP水平較預(yù)后不良者明顯降低(P0.01),而BDNF水平則明顯升高(P0.01)。腦梗死組血清BDNF水平與Ngb和MBP水平呈負(fù)相關(guān)(r=-0.654,P0.05;r=-0.768,P0.05),Ngb與MBP水平呈正相關(guān)(r=0.622,P0.05)。結(jié)論 Ngb、BDNF和MBP均參與急性腦梗死的發(fā)生、發(fā)展,監(jiān)測(cè)其水平變化對(duì)評(píng)估急性腦梗死的病情及預(yù)后具有重要的臨床意義。
[Abstract]:Objective to observe the changes of brain protein (Ngb), (Ngb),) brain-derived neurotrophic factor (BDNF) and myelin basic protein (MBP) in patients with acute cerebral infarction and their relationship with severity and prognosis. Methods from January 2012 to December 2015, 126 patients with acute cerebral infarction (cerebral infarction group) and 30 healthy subjects (control group) were selected. The changes of serum Ngb,BDNF and MBP levels were compared between the two groups, and the relationship between the indexes and the degree of nerve function injury, the size of cerebral infarction and the prognosis, and the correlation between the indexes were observed. Results compared with the control group, the serum Ngb and MBP in the cerebral infarction group were significantly increased (P0.01), while the BDNF was significantly decreased (P0.01). The level of serum Ngb and MBP increased with the severity of nerve function injury and the area of cerebral infarction (P0.01), BDNF decreased (P0.01). The levels of Ngb and MBP in patients with good prognosis were significantly lower than those in patients with poor prognosis (P0.01), while the levels of BDNF were significantly increased (P0.01). There was a negative correlation between serum BDNF level and Ngb and MBP levels in cerebral infarction group (r = -0.654, P 0.05 ~ (-0.768) P 0.05). There was a positive correlation between serum BDNF level and MBP level (r ~ (0.622) P 0.05). Conclusion both Ngb,BDNF and MBP are involved in the occurrence and development of acute cerebral infarction, and monitoring their level is of great clinical significance in evaluating the condition and prognosis of acute cerebral infarction.
【作者單位】： 上海市奉賢區(qū)中心醫(yī)院上海市第六人民醫(yī)院南院神經(jīng)內(nèi)科;
【分類號(hào)】：R743.33

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